The Role of VE-Cadherin in Vascular Morphogenesis and Permeability Control

VE-cadherin is an endothelial-specific cadherin that is essential for the formation and regulation of endothelial cell junctions. The adhesive function and expression levels of VE-cadherin at endothelial contacts are central determinants of the control of vascular permeability and leukocyte recruitment into tissue. In addition to controlling junctional integrity, VE-cadherin modulates a multitude of signaling processes that influence the behavior of endothelial cells, such as proliferation, survival, migration, polarity, expression of other junctional components, and tube and lumen formation of blood vessels. This chapter highlights recent progress in understanding how VE-cadherin modulates these various cellular processes. In addition, the current knowledge about how VE-cadhern participates in the regulation of the endothelial barrier in the adult organism is discussed.