化学
脾细胞
刀豆蛋白A
生长抑制
外周血单个核细胞
微生物学
药理学
体外
生物化学
分子生物学
生物
作者
Nasser A. Awadh Ali,James J. Ludtke,H Pilgrim,U Lindequist
出处
期刊:PubMed
日期:1996-09-01
卷期号:51 (9): 667-70
被引量:16
摘要
The effects of two phenolic compounds, hispolon and hispidin isolated from fruit bodies of the basidiomycete Inonotus hispidus (Bull. ex Fr.) Karst, were investigated on the chemiluminescence response by LPS- or zymosan-activated human mononuclear cells (MNC) and on the concanavalin A-induced proliferation of spleen lymphocytes of mouse in vitro. Both compounds showed inhibitory activity in the chemiluminescence-test with an IC50 (the concentration of test compound causing 50% effect) ranging from 4.4 to 4.6 micrograms/ml (20.3 to 21.2 microM) for hispolon and < 0.1 to 1.5 micrograms/ml (from < 0.4 microM to 6.0 microM) for hispidin. Antiproliferative effects have been achieved in the lymphocyte transformation test (LTT) by hispolon with an IC50 of 3.4 micrograms/ml (15.5 microM).
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