The Role of Polymeric IgA in the Pathogenesis of IgA Nephropathy

Primary IgA nephropathy is characterized by the presence of IgA at the mesangium level accompanied or not by other immunoglobulins in the absence of systemic liver disease. A similar immunofluorescence pattern has been observed in an array of diseases involving mucosal surfaces and the term syndrome of IgA nephropathy has been suggested [1].