Congenital hemangioma is the most common tumor of infancy. Usually it occurs singly in the skin. Occasionally multiple tumors are present and can involve other body organs. Congenital subglottic hemangioma is considered rare, but when it occurs can be life threatening. This article discusses the different options available for treatment of subglottic hemangioma and the course of treatment chosen for Baby S. taking into consideration her diagnosis, family situation, and the availability of an experimental drug therapy.