生物
亚科
先天免疫系统
促炎细胞因子
获得性免疫系统
柠檬酸杆菌
微生物学
免疫系统
寄主(生物学)
白细胞介素22
白细胞介素
免疫学
效应器
病菌
细胞因子
微生物群
细胞生物学
免疫
炎症
遗传学
基因
作者
Celine Eidenschenk,Sascha Rutz,Oliver Liesenfeld,Wenjun Ouyang
出处
期刊:Current Topics in Microbiology and Immunology
日期:2014-01-01
卷期号:: 213-236
被引量:52
标识
DOI:10.1007/978-3-662-43492-5_10
摘要
Interleukin (IL)-22 is a member of the IL-10 family of cytokines, which, besides IL-10, contains seven additional cytokines. Although the founding member IL-10 is an important immunoregulatory cytokine that represses both innate and adaptive immunity, the other family members preferentially target epithelial cells and enhance innate host defense mechanisms against various pathogens such as bacteria, yeast, and viruses. Based on their functions, the IL-10 family can be further divided into three subgroups, IL-10 itself, the IL-20 subfamily, and the IFNλ subfamily. IL-22 is the best-studied member of the IL-20 subfamily, and exemplifies the diverse biological effects of this subfamily. IL-22 elicits various innate immune responses from epithelial cells and is essential for host defense against several invading pathogens, including Citrobacter rodentium and Klebsiella pneumonia. IL-22 also protects tissue integrity and maintains the mucosal homeostasis. On the other hand, IL-22 is a proinflammatory cytokine with the capacity to amplify inflammatory responses, which might result in tissue damage, e.g., the IL-22-dependent necrosis of the small intestine during Toxoplasma gondii infection.
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