Modification of Pathologic T Classification for Non-small Cell Lung Cancer With Visceral Pleural Invasion

医学 内科学 分布式文件系统 肺癌 污渍 H&E染色 辅助治疗 胃肠病学 总体生存率 癌症 病理 免疫组织化学 染色 计算机安全 计算机科学
作者
Run-Bin Liang,Peng Li,Bob T. Li,Jie-Tian Jin,Valerie W. Rusch,David R. Jones,Yi‐Long Wu,Qing Liu,Jie Yang,Mu‐Zi Yang,Shuo Li,Hao Long,Jianhua Fu,Lanjun Zhang,Peng Lin,Tiehua Rong,Xue Hou,Suxia Lin,Hao‐Xian Yang
出处
期刊:Chest [Elsevier BV]
卷期号:160 (2): 754-764 被引量:15
标识
DOI:10.1016/j.chest.2021.03.022
摘要

Visceral pleural invasion (VPI) with PL1 or PL2 increases the T classification from T1 to T2 in non-small cell lung cancers (NSCLCs) ≤ 3 cm. We proposed a modified T classification based on VPI to guide adjuvant therapy.Is it reasonable to upstage PL1-positive cases from T1 to T2 for NSCLCs ≤ 3 cm?In total, 1,055 patients with resected NSCLC were retrospectively included. Tumor sections were restained with hematoxylin and eosin stain and Victoria blue elastic stain for the elastic layer. Disease-free survival (DFS) and overall survival (OS) were calculated by the Kaplan-Meier method. Subgroup analysis and a Cox proportional hazards model were used to further determine the impact of VPI on survival.The extent of VPI was diagnosed as PL0 in 824 patients, PL1 in 133 patients, and PL2 in 98 patients. The 5-year DFS rates of patients with PL0, PL1, and PL2 were 62.6%, 60.2%, and 28.8% (P < .01), whereas the corresponding 5-year OS rates were 78.6%, 74.4%, and 50.0% (P < .01), respectively. As predicted, the DFS and OS of patients with PL2 were much worse than those of patients with PL0 (P < .01) and PL1 (P < .01). However, both the DFS and OS of patients with PL0 and PL1 were comparable (DFS: P = .198; OS: P = .150). For node-negative cases, the DFS and OS of patients with PL0 and PL1 were also comparable (DFS: P = .468; OS: P = .388), but patients with PL2 had much worse DFS and OS than patients with PL0 (P < .01) and PL1 (P < .01). Multivariable analyses suggested that PL2, together with node positivity and poor cell differentiation, was an independent adverse prognostic factor.In NSCLCs ≤ 3 cm, tumors with PL1 should remain defined as T1, not T2. Overtreatment by adjuvant chemotherapy in node-negative NSCLCs ≤ 3 cm might be avoided in PL1 cases.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
4652376完成签到 ,获得积分10
3秒前
无情的幻嫣完成签到,获得积分10
3秒前
4秒前
李小小飞完成签到,获得积分10
5秒前
6秒前
hello完成签到,获得积分10
6秒前
我是老大应助无情的幻嫣采纳,获得10
6秒前
Roman完成签到,获得积分10
7秒前
slin_sjtu发布了新的文献求助10
9秒前
周周发布了新的文献求助20
9秒前
小党完成签到,获得积分10
9秒前
10秒前
昏睡的白桃完成签到,获得积分10
10秒前
小宇OvO发布了新的文献求助10
11秒前
jiaolulu发布了新的文献求助10
15秒前
量子星尘发布了新的文献求助10
15秒前
真的不想干活了完成签到,获得积分10
15秒前
美丽的依琴完成签到,获得积分10
16秒前
Xin完成签到,获得积分10
22秒前
Aurora.H完成签到,获得积分10
25秒前
25秒前
FashionBoy应助科研通管家采纳,获得10
26秒前
打打应助科研通管家采纳,获得10
26秒前
Jasper应助科研通管家采纳,获得10
26秒前
Ava应助科研通管家采纳,获得10
26秒前
顾矜应助科研通管家采纳,获得10
26秒前
上官若男应助科研通管家采纳,获得10
26秒前
duckspy发布了新的文献求助10
28秒前
28秒前
28秒前
xiaowan完成签到,获得积分10
29秒前
Terry完成签到,获得积分10
30秒前
张张张哈哈哈完成签到,获得积分10
30秒前
Research完成签到 ,获得积分10
30秒前
称心采枫完成签到 ,获得积分0
31秒前
31秒前
新新新新新发顶刊完成签到 ,获得积分10
32秒前
L3完成签到,获得积分10
33秒前
我是科研小能手完成签到,获得积分10
33秒前
风中的小丸子完成签到,获得积分10
34秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038201
求助须知:如何正确求助?哪些是违规求助? 3575940
关于积分的说明 11373987
捐赠科研通 3305747
什么是DOI,文献DOI怎么找? 1819274
邀请新用户注册赠送积分活动 892662
科研通“疑难数据库(出版商)”最低求助积分说明 815022