Spirometric Changes in Bronchodilation Tests as Predictors of Asthma Diagnosis and Treatment Response in Patients with FEV1 ≥ 80% Predicted

呼出气一氧化氮 医学 肺活量 支气管扩张 队列 内科学 肺活量测定 哮喘 前瞻性队列研究 气道 支气管扩张剂 胃肠病学 麻醉 心脏病学 扩散能力 肺功能
作者
Huijuan Hao,Wuping Bao,Yishu Xue,Yan Zhou,Zhixuan Huang,Dongning Yin,Yingying Zhang,Pengyu Zhang,Chengjian Lv,Lei Han,Xin Zhou,Jun-Feng Yin,Min Zhang
出处
期刊:The Journal of Allergy and Clinical Immunology: In Practice [Elsevier]
卷期号:9 (8): 3098-3108.e4 被引量:6
标识
DOI:10.1016/j.jaip.2021.03.015
摘要

Many patients with mild asthma are undiagnosed and untreated due to the low diagnostic sensitivity of bronchodilation test (BDT).To investigate whether airway reversibility in BDT and fractional exhaled nitric oxide (Feno) can predict the response to antiasthma therapy (RAT) in patients with suspected asthma.This open-label, prospective cohort study included patients with chronic recurrent asthma symptoms, normal FEV1, and negative BDT results. Inhaled corticosteroids and long-acting β agonists were given for 4 weeks. A positive RAT was defined as improved symptoms and an increase of more than 200 mL in FEV1 after inhaled corticosteroid/long-acting β agonist treatment. Lung tissues from another 19 patients who underwent pneumectomy for lung nodules were also analyzed.Of 110 patients recruited, 102 completed the study. Patients in the positive RAT group had a higher Feno and greater absolute (Δ) and percent (Δ%) improvements in forced vital capacity, FEV1, and forced expiratory flows (FEFs) in BDT than in the negative RAT group. The area under the curves of Feno, ΔFEV1%, ΔFEF25-75% (percent improvement in FEF at 25%-75% of forced vital capacity), and ΔFEF75% (percent improvement in FEF at 75% of forced vital capacity) for positive RAT were 0.703, 0.824, 0.736, and 0.710, with cutoff values of 33 parts per billion and 3.50%, 15.26%, and 26.04%, respectively. A joint model of Feno and ΔFEV1% increased the area under the curve to 0.880. Inflammatory cytokines were higher in the lung tissues of patients with predicted positive RAT than in those with predicted negative RAT.ΔFEV1% in BDT together with Feno predicted a positive RAT and an asthma diagnosis in patients with a normal FEV1 and negative BDT. Evidence of pathological changes increases the credibility of the predictive model.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
从容的夏瑶完成签到,获得积分10
刚刚
白石溪完成签到,获得积分10
1秒前
huihuiwang完成签到,获得积分10
2秒前
2秒前
可爱的柜子完成签到,获得积分10
2秒前
冰冰咖啡发布了新的文献求助10
4秒前
Jasper应助xiaogang127采纳,获得10
4秒前
Robin完成签到,获得积分20
4秒前
思源应助归tu采纳,获得10
5秒前
一半柠檬完成签到,获得积分10
6秒前
6秒前
星辰大海应助平常的蓝天采纳,获得10
6秒前
华仔应助云游的莫冷采纳,获得10
7秒前
直率笑翠发布了新的文献求助50
7秒前
7秒前
研友_VZG7GZ应助Wellnemo采纳,获得10
7秒前
领会发布了新的文献求助10
9秒前
9秒前
lll发布了新的文献求助10
11秒前
11秒前
英姑应助surou采纳,获得10
12秒前
王博士完成签到,获得积分10
13秒前
yy应助科研通管家采纳,获得10
13秒前
小洪俊熙应助科研通管家采纳,获得10
13秒前
萧水白应助科研通管家采纳,获得10
13秒前
wanci应助科研通管家采纳,获得10
13秒前
英姑应助科研通管家采纳,获得10
13秒前
上官若男应助科研通管家采纳,获得10
14秒前
在水一方应助科研通管家采纳,获得10
14秒前
小蘑菇应助科研通管家采纳,获得20
14秒前
Lucas应助曾经若枫采纳,获得30
14秒前
Lucas应助科研通管家采纳,获得10
14秒前
hucchongzi应助科研通管家采纳,获得10
14秒前
小二郎应助科研通管家采纳,获得10
14秒前
充电宝应助科研通管家采纳,获得10
14秒前
tuanheqi应助科研通管家采纳,获得50
14秒前
jevon应助科研通管家采纳,获得10
14秒前
小洪俊熙应助科研通管家采纳,获得10
14秒前
情怀应助科研通管家采纳,获得10
15秒前
高分求助中
歯科矯正学 第7版(或第5版) 1004
Semiconductor Process Reliability in Practice 1000
Smart but Scattered: The Revolutionary Executive Skills Approach to Helping Kids Reach Their Potential (第二版) 1000
Nickel superalloy market size, share, growth, trends, and forecast 2023-2030 600
GROUP-THEORY AND POLARIZATION ALGEBRA 500
Mesopotamian divination texts : conversing with the gods : sources from the first millennium BCE 500
Days of Transition. The Parsi Death Rituals(2011) 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3234027
求助须知:如何正确求助?哪些是违规求助? 2880431
关于积分的说明 8215492
捐赠科研通 2547980
什么是DOI,文献DOI怎么找? 1377371
科研通“疑难数据库(出版商)”最低求助积分说明 647869
邀请新用户注册赠送积分活动 623248