医学
贝伐单抗
结直肠癌
内科学
临床研究阶段
肿瘤科
性能状态
联合疗法
中性粒细胞减少症
化疗
癌症
临床终点
外科
随机对照试验
作者
Tetsuo Ishizaki,Junichi Mazaki,Masanobu Enomoto,Masatoshi Shigoka,Kenta Kasahara,Takaaki Matsudo,Hideaki Kawakita,Yuichi Nagakawa,Kenji Katsumata,Akihiko Tsuchida
出处
期刊:Anticancer Research
[Anticancer Research USA Inc.]
日期:2021-04-01
卷期号:41 (4): 2157-2163
被引量:8
标识
DOI:10.21873/anticanres.14988
摘要
Background: This study assessed the efficacy and safety of biweekly trifluridine and tipiracil hydrochloride (TAS-102) with bevacizumab combination therapy for patients with metastatic colorectal cancer (mCRC). Patients and Methods: We included 19 patients with mCRC who received TAS-102 and bevacizumab combination therapy biweekly as third-line chemotherapy. The primary endpoint was progression-free survival. Results: Patients had a median age of 73 years and most (73.4%) were men. The median progression-free and overall survival were 5.6 and 11.5 months, respectively. Five (26.3%) patients achieved a response and the disease control rate was 12/19 (63.1%). One patient (5.2%) experienced neutropenia grade 3 or more. The median time from baseline performance status 0/1 to worsening to 2 or more was 10.3 months. Conclusion: Biweekly TAS-102 plus bevacizumab facilitates tumor shrinkage by reducing the incidence of grade 3 or more neutropenia, improving survival, and maintaining performance status. This combination may represent a treatment option for patients with late-stage mCRC receiving third- or later-line therapy.
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