血管紧张素II
一氧化氮
一氧化氮合酶
内科学
氧化应激
内分泌学
医学
蛋白激酶A
激酶
化学
药理学
受体
生物化学
作者
Li Zhu,Zhen Liu,Liping Huang,Hourong Zhou,Yu Cao,Xueping Yang,Bingjin Wang,Zi-li Yang,Jing Chen
出处
期刊:Journal of Cardiovascular Pharmacology
[Ovid Technologies (Wolters Kluwer)]
日期:2021-04-30
卷期号:78 (1): e65-e76
被引量:4
标识
DOI:10.1097/fjc.0000000000001037
摘要
Abstract: There is increasing evidence that angiotensin (1-7) [Ang (1-7)] is an endogenous biologically active component of the renin–angiotensin system. However, the role of the Ang (1-7)-MasR axis in postresuscitation myocardial dysfunction (PRMD) and its associated mechanism are still unclear. In this study, we investigated the effect of the Ang (1-7)-MasR axis on myocardial injury after cardiac arrest-cardiopulmonary resuscitation-restoration of spontaneous circulation. We established a model of oxygen/glucose deprivation-reperfusion in myocardial cells in vitro and a rat model of cardiac arrest–cardiopulmonary resuscitation–restoration of spontaneous circulation in vivo. The cell apoptosis rate and the expression of the superoxide anion 3-nitrotyrosine were decreased in the Ang (1-7) group in vitro and in vivo. The mean arterial pressure was decreased, whereas +LVdp/dtmax and −LVdp/dtmax were increased in rats in the Ang (1-7) group. The mRNA and protein levels of Ang II type 1 receptor, MasR, phosphoinositide 3-kinase, protein kinase B, and endothelial nitric oxide synthase were increased in the Ang (1-7) group in vivo. These results indicate that the Ang (1-7)-MasR axis can alleviate PRMD by reducing myocardial tissue damage and oxidative stress through activation of the phosphoinositide 3-kinase–protein kinase B–endothelial nitric oxide synthase signaling pathway and provide a new direction for the clinical treatment of PRMD.
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