Heads or tails? The synthesis, self-assembly, properties and uses of betaine and betaine-like surfactants

Betaines are a key class of zwitterionic surfactant that exhibit particularly favorable properties, making them indispensable in modern formulation. Due to their composition, betaines are readily biodegradable, mild on the skin and exhibit some antimicrobial activity. Vital to their function, these surfactants self-assemble into diverse micellar geometries, some of which contribute to increased solution viscosity, and their surface activity results in strong detergency and foaming. As such, their behavior has been exploited in various applications from personal care (including shampoos and liquid soaps) to specific industrial fields (such as enhanced oil recovery). This review aims to inform the reader of the diverse range of different betaine and betaine-like surfactants that have been actively researched over the past three decades. Synthesis as well as both chemical and physical characterization of betaine surfactants are discussed, including small-angle scattering studies that indicate self-assembly structures and rheological data that demonstrates texture and flow. Stimulus responsive systems and exotic betaine analogs with enhanced functionality are also covered. Crucially, the connection between surfactant molecular architecture and function are highlighted, exemplifying precisely why zwitterionic betaine and related surfactants are so uniquely functional.