Risk prediction of occult lymph node metastasis in patients with clinical T1 through T2 N0 esophageal squamous cell carcinoma

医学 接收机工作特性 食管癌 内科学 淋巴结 神秘的 肿瘤科 转移 放射科 胃肠病学 食管鳞状细胞癌 癌症 阶段(地层学) 病理 古生物学 替代医学 生物
作者
Jae Kwang Yun,Hyeong Ryul Kim,Seung Il Park,Yong‐Hee Kim
出处
期刊:The Journal of Thoracic and Cardiovascular Surgery [Elsevier BV]
卷期号:164 (1): 265-275.e5 被引量:11
标识
DOI:10.1016/j.jtcvs.2021.10.033
摘要

To investigate long-term survival outcomes and develop a risk model for occult lymph node metastasis (LNM) in patients with clinical T1 through T2 N0 esophageal squamous cell carcinoma.From 2006 to 2018, 675 patients with clinical T1 through T2 N0 esophageal cancer who underwent upfront surgery were analyzed. The survival of patients with occult LNM was compared with that of 116 patients with clinical T1 through T2N+ cancer who underwent neoadjuvant therapy plus surgery. After randomly dividing the patients with clinical T1 through T2 N0 tumors into the training and testing sets, a risk model for occult LNM was developed and validated.Among patients with clinical T1 through T2 N0 esophageal cancer, occult LNM was found in 147 (21.8%) but not in 528 (78.2%). Patients with occult LNM had significantly worse prognosis than those without (P < .001), but showed similar outcomes to patients with clinical T1 through T2 N+ cancer (P = .981). According to the risk model, tumor maximum standardized uptake >3.8 (P = .002), histological differentiation grade (P = .015), tumor length >25 mm (P < .001), and advanced clinical T stage (P < .001) were independent risk factors for occult LNM in clinical T1 through T2 N0 cancer. A risk scoring system based on this model showed high accuracy (0.81) and good discriminant ability in both training sets (area under the receiver operating characteristic curve, 0.759 and testing area under the receiver operating characteristic curve, 0.743).Our risk scoring system for predicting occult LNM in clinical T1 through T2 N0 esophageal cancer has high accuracy and good discriminant ability.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
量子星尘发布了新的文献求助10
2秒前
恋雅颖月应助幸福大白采纳,获得10
2秒前
wh完成签到,获得积分10
2秒前
余淮完成签到,获得积分10
3秒前
平淡的初翠完成签到,获得积分10
3秒前
快乐一江发布了新的文献求助10
4秒前
邱型程应助屿落采纳,获得20
5秒前
鹤鸣完成签到,获得积分10
8秒前
8秒前
8秒前
10秒前
天真的高山完成签到,获得积分10
11秒前
善良海云完成签到,获得积分10
13秒前
ANG发布了新的文献求助10
13秒前
从容梦旋完成签到,获得积分10
15秒前
16秒前
酷波er应助liuyunhao7207采纳,获得10
16秒前
人生如梦应助健忘跳跳糖采纳,获得10
17秒前
17秒前
sihanzhiyu发布了新的文献求助10
17秒前
汉堡包应助dpp采纳,获得10
17秒前
在水一方应助hnu301采纳,获得10
17秒前
jbhb完成签到,获得积分20
18秒前
Colossus完成签到,获得积分10
18秒前
18秒前
20秒前
王哒哒完成签到,获得积分10
20秒前
英姑应助Fury采纳,获得10
22秒前
善良冷松发布了新的文献求助10
22秒前
二十五完成签到,获得积分10
23秒前
王哒哒发布了新的文献求助10
24秒前
24秒前
26秒前
27秒前
30秒前
30秒前
上官若男应助善良冷松采纳,获得10
31秒前
cccyq发布了新的文献求助10
31秒前
李健应助叶叶采纳,获得30
32秒前
33秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989406
求助须知:如何正确求助?哪些是违规求助? 3531522
关于积分的说明 11254187
捐赠科研通 3270174
什么是DOI,文献DOI怎么找? 1804901
邀请新用户注册赠送积分活动 882105
科研通“疑难数据库(出版商)”最低求助积分说明 809174