磷光
荧光
荧光寿命成像显微镜
自体荧光
临床前影像学
近红外光谱
材料科学
吸收(声学)
体内
化学
光学
生物
物理
生物技术
复合材料
作者
Baisong Chang,Daifeng Li,Ying Ren,Chunrong Qu,Xiaojing Shi,Ruiqi Liu,Hongguang Liu,Jie Tian,Zhenhua Hu,Taolei Sun,Zhen Cheng
标识
DOI:10.1038/s41551-021-00773-2
摘要
In the second near-infrared spectral window (NIR-II; with wavelengths of 1,000-1,700 nm), in vivo fluorescence imaging can take advantage of reduced tissue autofluorescence and lower light absorption and scattering by tissue. Here, we report the development and in vivo application of a NIR-II phosphorescent probe that has lifetimes of hundreds of microseconds and a Stokes shift of 430 nm. The probe is made of glutathione-capped copper-indium-selenium nanotubes, and in acidic environments (pH 5.5-6.5) switches from displaying fluorescence to phosphorescence. In xenograft models of osteosarcoma and breast cancer, intravenous or intratumoral injections of the probe enabled phosphorescence imaging at signal-to-background ratios, spatial resolutions and sensitivities higher than NIR-II fluorescence imaging with polymer-stabilized copper-indium-sulfide nanorods. Phosphorescence imaging may offer superior imaging performance for a range of biomedical uses.
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