Associations of multiple metals with bone mineral density: A population-based study in US adults

骨矿物 全国健康与营养检查调查 电感耦合等离子体质谱法 百分位 线性回归 人口 体质指数 Mercury(编程语言) 环境化学 环境卫生 动物科学 化学 质谱法 医学 骨质疏松症 内分泌学 色谱法 数学 统计 有机化学 程序设计语言 生物 计算机科学 机器学习
作者
Muhong Wei,Yuan Cui,Hao‐Long Zhou,Wenjing Song,Dongsheng Di,Ruyi Zhang,Qin Huang,Junan Liu,Qi Wang
出处
期刊:Chemosphere [Elsevier]
卷期号:282: 131150-131150 被引量:34
标识
DOI:10.1016/j.chemosphere.2021.131150
摘要

Epidemiologic studies focus on combined effects of multiple metals on bone mineral density (BMD) are scarce. Therefore, this study was conducted to examine associations of multiple metals exposure with BMD. Data of adults aged ≥20 years (n = 2545) from the US National Health and Nutrition Examination Survey (NHANES, 2011–2016) were collected and analyzed. Concentrations of metals were measured in blood (cadmium [Cd], lead [Pb], mercury [Hg], and manganese [Mn]) and serum (copper [Cu], selenium [Se], and zinc [Zn]) using inductively coupled plasma mass spectrometry and inductively coupled plasma dynamic reaction cell mass spectrometry, respectively. The weighted quantile sum (WQS) and Bayesian kernel machine regression (BKMR) models were performed to determine the joint effects of multiple metals exposure on lumbar and total BMD. The linear regression analyses showed Pb was negatively associated with BMDs. The WQS regression analyses revealed that the WQS index was inversely related to lumbar (β = −0.022, 95% CI: −0.036, −0.008) and total BMD (β = −0.015, 95% CI: −0.024, −0.006), and Se, Mn, and Pb were the main contributors for the combined effects. Additionally, nonlinear dose–response relationships between Pb, Mn, and Se and BMD, as well as a synergistic interaction of Pb and Mn, were found in the BKMR analyses. Our findings suggested co-exposure to Cd, Pb, Hg, Mn, Cu, Se, and Zn (above their 50th percentiles) was associated with reduced BMD, and Pb, Mn, and Se were the main contributors driving the overall effects.
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