毒力
生物膜
谷胱甘肽
发病机制
细菌
生物
毒力因子
微生物学
化学
生物化学
基因
免疫学
酶
遗传学
作者
Joanne Wei Kay Ku,Yunn‐Hwen Gan
出处
期刊:Redox biology
[Elsevier]
日期:2021-05-29
卷期号:44: 102012-102012
被引量:39
标识
DOI:10.1016/j.redox.2021.102012
摘要
Low molecular weight (LMW) thiols contain reducing sulfhydryl groups that are important for maintaining antioxidant defense in the cell. Aside from the traditional roles of LMW thiols as redox regulators in bacteria, glutathione (GSH) has been reported to affect virulence and bacterial pathogenesis. The role of GSH in virulence is diverse, including the activation of virulence gene expression and contributing to optimal biofilm formation. GSH can also be converted to hydrogen sulfide (H2S) which is important for the pathogenesis of certain bacteria. Besides GSH, some bacteria produce other LMW thiols such as mycothiol and bacillithiol that affect bacterial virulence. We discuss these newer reported functions of LMW thiols modulating bacterial pathogenesis either directly or indirectly and via modulation of the host immune system.
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