High-Density Lipoprotein Anti-Inflammatory Capacity and Incident Cardiovascular Events

医学 优势比 人口 胆固醇 C反应蛋白 脂蛋白 血管疾病 高密度脂蛋白 炎症 心脏病学 内分泌学 内科学 心肌梗塞 胃肠病学 环境卫生
作者
Congzhuo Jia,Josephine L.C. Anderson,Eke G. Gruppen,Lei Yu,Stephan J. L. Bakker,Robin P. F. Dullaart,Uwe J.F. Tietge
出处
期刊:Circulation [Ovid Technologies (Wolters Kluwer)]
卷期号:143 (20): 1935-1945 被引量:99
标识
DOI:10.1161/circulationaha.120.050808
摘要

The role of high-density lipoprotein (HDL) function in cardiovascular disease represents an important emerging concept. The present study investigated whether HDL anti-inflammatory capacity is prospectively associated with first cardiovascular events in the general population.HDL anti-inflammatory capacity was determined as its ability to suppress TNFα (tumor necrosis factor α)-induced VCAM-1 (vascular cell adhesion molecule-1) mRNA expression in endothelial cells in vitro (results expressed as achieved percent reduction by individual HDL related to the maximum TNFα effect with no HDL present). In a nested case-control design of the PREVEND (Prevention of Renal and Vascular End Stage Disease) study, 369 cases experiencing a first cardiovascular event (combined end point of death from cardiovascular causes, ischemic heart disease, nonfatal myocardial infarction, and coronary revascularization) during a median of 10.5 years of follow-up were identified and individually matched to 369 controls with respect to age, sex, smoking status, and HDL cholesterol. Baseline samples were available in 340 cases and 340 matched controls.HDL anti-inflammatory capacity was not correlated with HDL cholesterol or hsCRP (high-sensitivity C-reactive protein). HDL anti-inflammatory capacity was significantly lower in cases compared with controls (31.6% [15.7-44.2] versus 27.0% [7.4-36.1]; P<0.001) and was inversely associated with incident CVD in a fully adjusted model (odds ratio [OR] per 1 SD, 0.74 [CI, 0.61-0.90]; P=0.002). Furthermore, this association was approximately similar with all individual components of the cardiovascular disease end point. The HDL anti-inflammatory was not correlated with cholesterol efflux capacity (r=-0.02; P>0.05). When combining these 2 HDL function metrics in 1 model, both were significantly and independently associated with incident cardiovascular disease in a fully adjusted model (efflux: OR per 1 SD, 0.74; P=0.002; anti-inflammatory capacity: OR per 1 SD, 0.66; P<0.001). Adding HDL anti-inflammatory capacity improved risk prediction by the Framingham risk score, with a model likelihood-ratio statistic increase from 10.50 to 20.40 (P=0.002).The HDL anti-inflammatory capacity, reflecting vascular protection against key steps in atherogenesis, was inversely associated with incident cardiovascular events in a general population cohort, independent of HDL cholesterol and HDL cholesterol efflux capacity. Adding HDL anti-inflammatory capacity to the Framingham risk score improves risk prediction.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
3秒前
4秒前
ZD发布了新的文献求助10
5秒前
丘比特应助qdsj2033采纳,获得30
5秒前
5秒前
6秒前
8秒前
龙骑士25发布了新的文献求助10
8秒前
漂亮的魂幽完成签到,获得积分10
9秒前
传奇3应助wahj10224采纳,获得10
10秒前
10秒前
知性的冰棍完成签到,获得积分10
10秒前
无辜秋珊发布了新的文献求助10
10秒前
10秒前
学不动了完成签到,获得积分20
13秒前
打工人完成签到,获得积分20
14秒前
瑜木发布了新的文献求助10
14秒前
19秒前
太懂我了吧完成签到,获得积分10
19秒前
zycorner完成签到,获得积分10
22秒前
wahj10224发布了新的文献求助10
23秒前
研友_LN7x6n发布了新的文献求助10
24秒前
落后鹭洋完成签到,获得积分10
25秒前
25秒前
杨某完成签到,获得积分10
25秒前
天天天王发布了新的文献求助10
25秒前
MoriZhang完成签到,获得积分10
26秒前
26秒前
田様应助lan采纳,获得30
27秒前
木木发布了新的文献求助10
27秒前
liwai发布了新的文献求助10
28秒前
Return完成签到,获得积分10
28秒前
无敌最俊朗应助(∩_∩)采纳,获得10
29秒前
32秒前
32秒前
曾经的苑博完成签到,获得积分10
32秒前
科研通AI2S应助学不动了采纳,获得10
32秒前
liwai完成签到,获得积分10
33秒前
小二郎应助友好的小虾米采纳,获得10
33秒前
Gergeo应助好好想想采纳,获得20
33秒前
高分求助中
Evolution 3rd edition 1500
保险藏宝图 1000
Lire en communiste 1000
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 700
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 700
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3184721
求助须知:如何正确求助?哪些是违规求助? 2835020
关于积分的说明 8002635
捐赠科研通 2497407
什么是DOI,文献DOI怎么找? 1332826
科研通“疑难数据库(出版商)”最低求助积分说明 636696
邀请新用户注册赠送积分活动 604068