High-Density Lipoprotein Anti-Inflammatory Capacity and Incident Cardiovascular Events

医学 优势比 人口 胆固醇 C反应蛋白 脂蛋白 血管疾病 高密度脂蛋白 炎症 心脏病学 内分泌学 内科学 心肌梗塞 胃肠病学 环境卫生
作者
Congzhuo Jia,Josephine L.C. Anderson,Eke G. Gruppen,Lei Yu,Stephan J. L. Bakker,Robin P. F. Dullaart,Uwe J.F. Tietge
出处
期刊:Circulation [Ovid Technologies (Wolters Kluwer)]
卷期号:143 (20): 1935-1945 被引量:99
标识
DOI:10.1161/circulationaha.120.050808
摘要

The role of high-density lipoprotein (HDL) function in cardiovascular disease represents an important emerging concept. The present study investigated whether HDL anti-inflammatory capacity is prospectively associated with first cardiovascular events in the general population.HDL anti-inflammatory capacity was determined as its ability to suppress TNFα (tumor necrosis factor α)-induced VCAM-1 (vascular cell adhesion molecule-1) mRNA expression in endothelial cells in vitro (results expressed as achieved percent reduction by individual HDL related to the maximum TNFα effect with no HDL present). In a nested case-control design of the PREVEND (Prevention of Renal and Vascular End Stage Disease) study, 369 cases experiencing a first cardiovascular event (combined end point of death from cardiovascular causes, ischemic heart disease, nonfatal myocardial infarction, and coronary revascularization) during a median of 10.5 years of follow-up were identified and individually matched to 369 controls with respect to age, sex, smoking status, and HDL cholesterol. Baseline samples were available in 340 cases and 340 matched controls.HDL anti-inflammatory capacity was not correlated with HDL cholesterol or hsCRP (high-sensitivity C-reactive protein). HDL anti-inflammatory capacity was significantly lower in cases compared with controls (31.6% [15.7-44.2] versus 27.0% [7.4-36.1]; P<0.001) and was inversely associated with incident CVD in a fully adjusted model (odds ratio [OR] per 1 SD, 0.74 [CI, 0.61-0.90]; P=0.002). Furthermore, this association was approximately similar with all individual components of the cardiovascular disease end point. The HDL anti-inflammatory was not correlated with cholesterol efflux capacity (r=-0.02; P>0.05). When combining these 2 HDL function metrics in 1 model, both were significantly and independently associated with incident cardiovascular disease in a fully adjusted model (efflux: OR per 1 SD, 0.74; P=0.002; anti-inflammatory capacity: OR per 1 SD, 0.66; P<0.001). Adding HDL anti-inflammatory capacity improved risk prediction by the Framingham risk score, with a model likelihood-ratio statistic increase from 10.50 to 20.40 (P=0.002).The HDL anti-inflammatory capacity, reflecting vascular protection against key steps in atherogenesis, was inversely associated with incident cardiovascular events in a general population cohort, independent of HDL cholesterol and HDL cholesterol efflux capacity. Adding HDL anti-inflammatory capacity to the Framingham risk score improves risk prediction.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
cici发布了新的文献求助30
刚刚
桐桐应助123采纳,获得10
刚刚
1秒前
trayheep完成签到,获得积分10
2秒前
qdysci发布了新的文献求助10
2秒前
murphy发布了新的文献求助10
3秒前
Monster发布了新的文献求助10
4秒前
荧光绿土豆泥完成签到 ,获得积分10
4秒前
orixero应助wwww采纳,获得10
4秒前
mmknnk完成签到,获得积分10
5秒前
科研通AI2S应助胡嘉颖采纳,获得10
5秒前
Xifandoufu完成签到,获得积分10
5秒前
5秒前
光亮的冰巧完成签到,获得积分10
6秒前
俎树同发布了新的文献求助10
6秒前
努力毕业中完成签到,获得积分10
7秒前
7秒前
9秒前
思源应助洛伊儿采纳,获得10
10秒前
YuexYue完成签到,获得积分10
10秒前
10秒前
JamesPei应助如意纸鹤采纳,获得10
10秒前
10秒前
充电宝应助wwwyyy采纳,获得10
10秒前
11秒前
11秒前
HuanChen应助YJJ采纳,获得10
11秒前
12秒前
山晴发布了新的文献求助10
12秒前
耳机单蹦发布了新的文献求助10
13秒前
fabea完成签到,获得积分10
13秒前
13秒前
14秒前
不吃香菜完成签到,获得积分10
14秒前
wang发布了新的文献求助10
14秒前
天天快乐应助努力毕业中采纳,获得10
15秒前
在水一方应助monster0101采纳,获得10
15秒前
15秒前
yyyy6666发布了新的文献求助10
16秒前
高分求助中
Evolution 3rd edition 1500
保险藏宝图 1000
Lire en communiste 1000
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 700
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 700
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
2-Acetyl-1-pyrroline: an important aroma component of cooked rice 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3181497
求助须知:如何正确求助?哪些是违规求助? 2831768
关于积分的说明 7986447
捐赠科研通 2493734
什么是DOI,文献DOI怎么找? 1330309
科研通“疑难数据库(出版商)”最低求助积分说明 635955
版权声明 602955