已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

High-Density Lipoprotein Anti-Inflammatory Capacity and Incident Cardiovascular Events

医学 优势比 人口 胆固醇 C反应蛋白 脂蛋白 血管疾病 高密度脂蛋白 炎症 心脏病学 内分泌学 内科学 心肌梗塞 胃肠病学 环境卫生
作者
Congzhuo Jia,Josephine L.C. Anderson,Eke G. Gruppen,Lei Yu,Stephan J. L. Bakker,Robin P. F. Dullaart,Uwe J.F. Tietge
出处
期刊:Circulation [Ovid Technologies (Wolters Kluwer)]
卷期号:143 (20): 1935-1945 被引量:99
标识
DOI:10.1161/circulationaha.120.050808
摘要

The role of high-density lipoprotein (HDL) function in cardiovascular disease represents an important emerging concept. The present study investigated whether HDL anti-inflammatory capacity is prospectively associated with first cardiovascular events in the general population.HDL anti-inflammatory capacity was determined as its ability to suppress TNFα (tumor necrosis factor α)-induced VCAM-1 (vascular cell adhesion molecule-1) mRNA expression in endothelial cells in vitro (results expressed as achieved percent reduction by individual HDL related to the maximum TNFα effect with no HDL present). In a nested case-control design of the PREVEND (Prevention of Renal and Vascular End Stage Disease) study, 369 cases experiencing a first cardiovascular event (combined end point of death from cardiovascular causes, ischemic heart disease, nonfatal myocardial infarction, and coronary revascularization) during a median of 10.5 years of follow-up were identified and individually matched to 369 controls with respect to age, sex, smoking status, and HDL cholesterol. Baseline samples were available in 340 cases and 340 matched controls.HDL anti-inflammatory capacity was not correlated with HDL cholesterol or hsCRP (high-sensitivity C-reactive protein). HDL anti-inflammatory capacity was significantly lower in cases compared with controls (31.6% [15.7-44.2] versus 27.0% [7.4-36.1]; P<0.001) and was inversely associated with incident CVD in a fully adjusted model (odds ratio [OR] per 1 SD, 0.74 [CI, 0.61-0.90]; P=0.002). Furthermore, this association was approximately similar with all individual components of the cardiovascular disease end point. The HDL anti-inflammatory was not correlated with cholesterol efflux capacity (r=-0.02; P>0.05). When combining these 2 HDL function metrics in 1 model, both were significantly and independently associated with incident cardiovascular disease in a fully adjusted model (efflux: OR per 1 SD, 0.74; P=0.002; anti-inflammatory capacity: OR per 1 SD, 0.66; P<0.001). Adding HDL anti-inflammatory capacity improved risk prediction by the Framingham risk score, with a model likelihood-ratio statistic increase from 10.50 to 20.40 (P=0.002).The HDL anti-inflammatory capacity, reflecting vascular protection against key steps in atherogenesis, was inversely associated with incident cardiovascular events in a general population cohort, independent of HDL cholesterol and HDL cholesterol efflux capacity. Adding HDL anti-inflammatory capacity to the Framingham risk score improves risk prediction.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
大个应助贝尔摩德采纳,获得10
1秒前
123完成签到,获得积分10
5秒前
10秒前
思明发布了新的文献求助10
10秒前
可耐的思远完成签到 ,获得积分10
12秒前
12秒前
apb完成签到 ,获得积分10
12秒前
酷波er应助斯文的水池采纳,获得10
14秒前
灵山剑侠发布了新的文献求助20
19秒前
hala安胖胖完成签到,获得积分10
24秒前
26秒前
29秒前
30秒前
hala安胖胖发布了新的文献求助10
30秒前
32秒前
33秒前
33秒前
超级泽洋发布了新的文献求助10
33秒前
共产主义接班人完成签到,获得积分10
34秒前
李默庵啊发布了新的文献求助30
35秒前
35秒前
深情安青应助碧落黄泉诗采纳,获得10
36秒前
XXXX发布了新的文献求助10
37秒前
38秒前
39秒前
camellia发布了新的文献求助10
40秒前
41秒前
43秒前
听风随影完成签到 ,获得积分10
43秒前
Bell发布了新的文献求助10
43秒前
李默庵啊完成签到,获得积分10
46秒前
小奶瓶_完成签到 ,获得积分10
46秒前
noeru完成签到,获得积分10
46秒前
46秒前
特梅头发布了新的文献求助10
46秒前
Samsu完成签到 ,获得积分10
47秒前
47秒前
田様应助超级泽洋采纳,获得10
48秒前
49秒前
49秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
Aspects of Babylonian celestial divination: the lunar eclipse tablets of Enūma Anu Enlil 500
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
India's foreign trade policy and its performance in the world economy 450
Dictionary of socialism 350
Mixed-anion Compounds 300
Geochemistry, 2nd Edition 地球化学经典教科书第二版 300
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3196434
求助须知:如何正确求助?哪些是违规求助? 2845197
关于积分的说明 8053394
捐赠科研通 2509844
什么是DOI,文献DOI怎么找? 1342028
科研通“疑难数据库(出版商)”最低求助积分说明 639304
邀请新用户注册赠送积分活动 608585