High-Density Lipoprotein Anti-Inflammatory Capacity and Incident Cardiovascular Events

医学 优势比 人口 胆固醇 C反应蛋白 脂蛋白 血管疾病 高密度脂蛋白 炎症 心脏病学 内分泌学 内科学 心肌梗塞 胃肠病学 环境卫生
作者
Congzhuo Jia,Josephine L.C. Anderson,Eke G. Gruppen,Lei Yu,Stephan J. L. Bakker,Robin P. F. Dullaart,Uwe J.F. Tietge
出处
期刊:Circulation [Ovid Technologies (Wolters Kluwer)]
卷期号:143 (20): 1935-1945 被引量:99
标识
DOI:10.1161/circulationaha.120.050808
摘要

The role of high-density lipoprotein (HDL) function in cardiovascular disease represents an important emerging concept. The present study investigated whether HDL anti-inflammatory capacity is prospectively associated with first cardiovascular events in the general population.HDL anti-inflammatory capacity was determined as its ability to suppress TNFα (tumor necrosis factor α)-induced VCAM-1 (vascular cell adhesion molecule-1) mRNA expression in endothelial cells in vitro (results expressed as achieved percent reduction by individual HDL related to the maximum TNFα effect with no HDL present). In a nested case-control design of the PREVEND (Prevention of Renal and Vascular End Stage Disease) study, 369 cases experiencing a first cardiovascular event (combined end point of death from cardiovascular causes, ischemic heart disease, nonfatal myocardial infarction, and coronary revascularization) during a median of 10.5 years of follow-up were identified and individually matched to 369 controls with respect to age, sex, smoking status, and HDL cholesterol. Baseline samples were available in 340 cases and 340 matched controls.HDL anti-inflammatory capacity was not correlated with HDL cholesterol or hsCRP (high-sensitivity C-reactive protein). HDL anti-inflammatory capacity was significantly lower in cases compared with controls (31.6% [15.7-44.2] versus 27.0% [7.4-36.1]; P<0.001) and was inversely associated with incident CVD in a fully adjusted model (odds ratio [OR] per 1 SD, 0.74 [CI, 0.61-0.90]; P=0.002). Furthermore, this association was approximately similar with all individual components of the cardiovascular disease end point. The HDL anti-inflammatory was not correlated with cholesterol efflux capacity (r=-0.02; P>0.05). When combining these 2 HDL function metrics in 1 model, both were significantly and independently associated with incident cardiovascular disease in a fully adjusted model (efflux: OR per 1 SD, 0.74; P=0.002; anti-inflammatory capacity: OR per 1 SD, 0.66; P<0.001). Adding HDL anti-inflammatory capacity improved risk prediction by the Framingham risk score, with a model likelihood-ratio statistic increase from 10.50 to 20.40 (P=0.002).The HDL anti-inflammatory capacity, reflecting vascular protection against key steps in atherogenesis, was inversely associated with incident cardiovascular events in a general population cohort, independent of HDL cholesterol and HDL cholesterol efflux capacity. Adding HDL anti-inflammatory capacity to the Framingham risk score improves risk prediction.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Owen应助Yuanyuan采纳,获得10
4秒前
7秒前
9秒前
沉默傲芙完成签到 ,获得积分10
9秒前
10秒前
Murphy完成签到,获得积分10
13秒前
wusj120发布了新的文献求助10
15秒前
19秒前
奥里给完成签到 ,获得积分10
21秒前
一粟的粉r完成签到 ,获得积分10
24秒前
苦逼的科研汪完成签到 ,获得积分10
24秒前
张帆远航完成签到,获得积分10
26秒前
诚心仙人掌完成签到,获得积分10
28秒前
柒月完成签到 ,获得积分10
28秒前
30秒前
刘歌完成签到 ,获得积分10
34秒前
35秒前
司徒无剑发布了新的文献求助20
36秒前
迷你的雁枫完成签到 ,获得积分10
40秒前
韦雪莲完成签到 ,获得积分10
43秒前
43秒前
木木完成签到,获得积分10
43秒前
生命奋斗发布了新的文献求助10
49秒前
wang完成签到 ,获得积分10
52秒前
52秒前
55秒前
寻道图强应助gnr2000采纳,获得30
55秒前
司徒无剑完成签到,获得积分10
55秒前
我就想看看文献完成签到 ,获得积分10
58秒前
JaneChen完成签到 ,获得积分10
1分钟前
gnr2000完成签到,获得积分0
1分钟前
1分钟前
生命奋斗完成签到,获得积分10
1分钟前
Ruuo616完成签到 ,获得积分10
1分钟前
zenabia完成签到 ,获得积分10
1分钟前
范白容完成签到 ,获得积分10
1分钟前
xingxing完成签到 ,获得积分10
1分钟前
ruiii完成签到 ,获得积分10
1分钟前
SC完成签到 ,获得积分10
1分钟前
666星爷完成签到,获得积分10
1分钟前
高分求助中
Evolution 3rd edition 1500
保险藏宝图 1000
Lire en communiste 1000
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 700
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 700
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3183763
求助须知:如何正确求助?哪些是违规求助? 2833823
关于积分的说明 7995626
捐赠科研通 2496089
什么是DOI,文献DOI怎么找? 1331890
科研通“疑难数据库(出版商)”最低求助积分说明 636455
邀请新用户注册赠送积分活动 603625