High-Density Lipoprotein Anti-Inflammatory Capacity and Incident Cardiovascular Events

医学 优势比 人口 胆固醇 C反应蛋白 脂蛋白 血管疾病 高密度脂蛋白 炎症 心脏病学 内分泌学 内科学 心肌梗塞 胃肠病学 环境卫生
作者
Congzhuo Jia,Josephine L.C. Anderson,Eke G. Gruppen,Lei Yu,Stephan J. L. Bakker,Robin P. F. Dullaart,Uwe J.F. Tietge
出处
期刊:Circulation [Ovid Technologies (Wolters Kluwer)]
卷期号:143 (20): 1935-1945 被引量:99
标识
DOI:10.1161/circulationaha.120.050808
摘要

The role of high-density lipoprotein (HDL) function in cardiovascular disease represents an important emerging concept. The present study investigated whether HDL anti-inflammatory capacity is prospectively associated with first cardiovascular events in the general population.HDL anti-inflammatory capacity was determined as its ability to suppress TNFα (tumor necrosis factor α)-induced VCAM-1 (vascular cell adhesion molecule-1) mRNA expression in endothelial cells in vitro (results expressed as achieved percent reduction by individual HDL related to the maximum TNFα effect with no HDL present). In a nested case-control design of the PREVEND (Prevention of Renal and Vascular End Stage Disease) study, 369 cases experiencing a first cardiovascular event (combined end point of death from cardiovascular causes, ischemic heart disease, nonfatal myocardial infarction, and coronary revascularization) during a median of 10.5 years of follow-up were identified and individually matched to 369 controls with respect to age, sex, smoking status, and HDL cholesterol. Baseline samples were available in 340 cases and 340 matched controls.HDL anti-inflammatory capacity was not correlated with HDL cholesterol or hsCRP (high-sensitivity C-reactive protein). HDL anti-inflammatory capacity was significantly lower in cases compared with controls (31.6% [15.7-44.2] versus 27.0% [7.4-36.1]; P<0.001) and was inversely associated with incident CVD in a fully adjusted model (odds ratio [OR] per 1 SD, 0.74 [CI, 0.61-0.90]; P=0.002). Furthermore, this association was approximately similar with all individual components of the cardiovascular disease end point. The HDL anti-inflammatory was not correlated with cholesterol efflux capacity (r=-0.02; P>0.05). When combining these 2 HDL function metrics in 1 model, both were significantly and independently associated with incident cardiovascular disease in a fully adjusted model (efflux: OR per 1 SD, 0.74; P=0.002; anti-inflammatory capacity: OR per 1 SD, 0.66; P<0.001). Adding HDL anti-inflammatory capacity improved risk prediction by the Framingham risk score, with a model likelihood-ratio statistic increase from 10.50 to 20.40 (P=0.002).The HDL anti-inflammatory capacity, reflecting vascular protection against key steps in atherogenesis, was inversely associated with incident cardiovascular events in a general population cohort, independent of HDL cholesterol and HDL cholesterol efflux capacity. Adding HDL anti-inflammatory capacity to the Framingham risk score improves risk prediction.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
lei发布了新的文献求助10
1秒前
Yisi发布了新的文献求助10
3秒前
α(阿尔法)完成签到 ,获得积分10
3秒前
橘子海发布了新的文献求助10
4秒前
4秒前
大个应助山见山采纳,获得10
5秒前
5秒前
7秒前
az发布了新的文献求助10
9秒前
fabian完成签到,获得积分10
10秒前
10秒前
Owen应助dd采纳,获得10
11秒前
深情安青应助Ll采纳,获得10
11秒前
12秒前
13秒前
三石盟约完成签到,获得积分10
13秒前
成诗怡完成签到,获得积分20
14秒前
14秒前
小马宝利完成签到,获得积分20
17秒前
极光发布了新的文献求助10
17秒前
小马甲应助wenying采纳,获得10
17秒前
18秒前
王芋圆完成签到,获得积分10
18秒前
21秒前
达利园完成签到,获得积分10
22秒前
sduwl完成签到,获得积分10
24秒前
Terahertz完成签到 ,获得积分10
24秒前
24秒前
金刚经应助达利园采纳,获得10
26秒前
Ll发布了新的文献求助10
27秒前
Akim应助lf采纳,获得10
29秒前
lei完成签到,获得积分20
30秒前
wenying发布了新的文献求助10
30秒前
wyuanhu完成签到,获得积分10
32秒前
自由的刺猬完成签到,获得积分10
38秒前
zhangzhang完成签到,获得积分10
39秒前
陌陌应助CYC采纳,获得10
41秒前
金刚经应助吴红波采纳,获得10
42秒前
43秒前
远山完成签到 ,获得积分10
43秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
ALA生合成不全マウスでの糖代謝異常の分子機構解析 520
安全防范技术与工程 500
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
2-Acetyl-1-pyrroline: an important aroma component of cooked rice 500
A real-time energy management strategy based on fuzzy control and ECMS for PHEVs 400
2024 Medicinal Chemistry Reviews 400
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3190867
求助须知:如何正确求助?哪些是违规求助? 2840066
关于积分的说明 8026815
捐赠科研通 2503309
什么是DOI,文献DOI怎么找? 1336841
科研通“疑难数据库(出版商)”最低求助积分说明 637971
邀请新用户注册赠送积分活动 606296