药理学
阿立哌唑
化学
部分
受体
药品
西洛他唑
哌唑嗪
立体化学
医学
敌手
生物化学
精神科
精神分裂症(面向对象编程)
阿司匹林
作者
Letitia Meiring,Jacobus P. Petzer,Anél Petzer
出处
期刊:Mini-reviews in Medicinal Chemistry
[Bentham Science]
日期:2018-04-30
卷期号:18 (10): 828-836
被引量:10
标识
DOI:10.2174/1389557517666170927141323
摘要
The 3,4-dihydro-2(1H)-quinolinone moiety is present in a number of pharmacologically active compounds. These include FDA approved drugs such as cilostazol, carteolol and aripiprazole as well as numerous experimental compounds. Compounds containing the 3,4-dihydro-2(1H)-quinolinone moiety also exhibit a variety of activities in both the peripheral and central tissues, which includes phosphodiesterase inhibition, blocking of β-adrenergic receptors, antagonism of vasopressin receptors and interaction with serotonin and dopamine receptors. Based on its versatility in drug design and action, this paper reviews the pharmacological actions of compounds containing the 3,4-dihydro-2(1H)- quinolinone scaffold with emphasis being placed on the most important and significant members of each activity class. Keywords: Aripiprazole, carteolol, cilostazol, 3, 4-dihydro-2(1H)-quinolinone, pharmacology, drug design.
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