This article reviews and critically examines 77 journal articles published from 2005 to 2016 on the fuzzy-set qualitative comparative analysis (fsQCA) applied in business and management research on the fields of entrepreneurship and innovation research. The findings reveal that the number of fsQCA applications has sharply increased during the past few years. Stemming from the systematic literature review, core aspects dealing with firm performance and innovation are identified. Ultimately, we provide promising areas with future potential for the application of fsQCA such as the elaboration of the antecedents leading to business model innovation.