肽
纳米医学
化学
阿霉素
重组DNA
癌症研究
药物输送
纳米颗粒
病毒学
纳米技术
生物化学
材料科学
生物
基因
有机化学
化疗
遗传学
作者
Wenjun Shan,Deliang Zhang,Yun‐Long Wu,Xiaolin Lv,Bin Hu,Xi Zhou,Shefang Ye,Shengli Bi,Lei Ren,Xianzhong Zhang
标识
DOI:10.1016/j.nano.2017.12.002
摘要
Virus-mimicking particles have made great contribution to the development of nanomedicine. Herein, several modularized peptides (lipophilic NS5A peptide, 6xHis tag, and tumor-targeting peptide RGD) were genetically inserted into the C-terminus and the major immunodominant loop region (MIR) of hepatitis B core protein (HBc), respectively. This study demonstrated that the recombinant HBc-based VLPs could participate in self-assembly of monodisperse nanoparticles (33.6±3.5nm) with well-defined morphology, and DOX can be packaged into VLNPs without any chemical modification. Moreover, the HBc-based VLPs could specifically target to cancer cells via the interaction with overexpressed integrin αvβ3. The treatment with DOX-loaded HBc-based VLPs showed a significant inhibition of tumor growth (90.7% TGI) and less cardiotoxicity in B16F10 tumor-bearing mice models than that with the free DOX. Importantly, the results may offer an easy way to give a variety of ideal functional modulations for VLPs, thereby extending its potential biomedicine applications.
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