牙槽
牙周炎
医学
牙科
结扎
臼齿
抗酒石酸酸性磷酸酶
骨整合
苏木精
炎症
下颌第一磨牙
种植周围炎
病理
内科学
破骨细胞
植入
外科
免疫组织化学
受体
作者
Sarah Hiyari,Ryan L. Wong,Aline Yaghsezian,Azadi Naghibi,Sotirios Tetradis,Paulo M. Camargo,Flávia Q. Pirih
摘要
Abstract Aim Peri‐implantitis ( PI ), inflammation around dental implants, shares characteristics with periodontitis ( PD ). However, PI is more difficult to control and treat, and detailed pathophysiology is unclear. We aimed to compare PI and PD progression utilizing a murine model. Materials and Methods Four‐week‐old male C57 BL /6J mice had their left maxillary molars extracted. Implants were placed in healed extraction sockets and osseointegrated. Ligatures were tied around the implants and second molars. Controls did not receive ligatures. Mice were sacrificed 1 week, 1 and 3 months ( n ≥ 5/group/time point) post‐ligature placement. Bone loss analysis was performed. Histology was performed for: haematoxylin and eosin (H&E), tartrate‐resistant acid phosphatase ( TRAP ), matrix metalloproteinase‐8 ( MMP ‐8), nuclear factor kappa‐light‐chain enhancer of activated B cells ( NF ‐κB), toluidine blue and calcein. Results PI showed statistically greater bone loss compared to PD at 1 and 3 months. At 3 months, 20% of implants in PI exfoliated; no natural teeth exfoliated in PD . H&E revealed that alveolar bone surrounding implants in PI appeared less dense compared to PD . PI presented with increased osteoclasts, MMP ‐8 and NF ‐κB, compared to PD . Conclusion PI exhibited greater tissue and bone destruction compared to PD . Future studies will characterize the pathophysiological differences between the two conditions.
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