High-intensity interval training and calorie restriction promote remodeling of glucose and lipid metabolism in diet-induced obesity

内科学 内分泌学 高强度间歇训练 产热 热卡限制 白色脂肪组织 间歇训练 脂肪组织 褐色脂肪组织 有氧运动 骨骼肌 医学 化学
作者
Rachel Davis,Jacob E. Halbrooks,Emily E. Watkins,Gordon Fisher,Gary R. Hunter,Tim R. Nagy,Eric P. Plaisance
出处
期刊:American Journal of Physiology-endocrinology and Metabolism [American Physiological Society]
卷期号:313 (2): E243-E256 被引量:45
标识
DOI:10.1152/ajpendo.00445.2016
摘要

Calorie restriction (CR) decreases adiposity, but the magnitude and defense of weight loss is less than predicted due to reductions in total daily energy expenditure (TEE). The purpose of the current investigation was to determine whether high-intensity interval training (HIIT) would increase markers of sympathetic activation in white adipose tissue (WAT) and rescue CR-mediated reductions in EE to a greater extent than moderate-intensity aerobic exercise training (MIT). Thirty-two 5-wk-old male C57BL/6J mice were placed on ad libitum HFD for 11 wk, followed by randomization to one of four groups ( n = 8/group) for an additional 15 wk: 1) CON (remain on HFD), 2) CR (25% lower energy intake), 3) CR + HIIT (25% energy deficit created by 12.5% CR and 12.5% EE through HIIT), and 4) CR + MIT (25% energy deficit created by 12.5% CR and 12.5% EE through MIT). Markers of adipose thermogenesis ( Ucp1, Prdm16, Dio2, and Fgf21) were unchanged in either exercise group in inguinal or epididymal WAT, whereas CR + HIIT decreased Ucp1 expression in retroperitoneal WAT and brown adipose tissue. HIIT rescued CR-mediated reductions in lean body mass (LBM) and resting energy expenditure (REE), and both were associated with improvements in glucose/insulin tolerance. Improvements in glucose metabolism in the CR + HIIT group appear to be linked to a molecular signature that enhances glucose and lipid storage in skeletal muscle. Exercise performed at either moderate or high intensity does not increase markers of adipose thermogenesis when performed in the presence of CR but remodels skeletal muscle metabolic and thermogenic capacity.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
JIE完成签到,获得积分10
刚刚
houjibofa发布了新的文献求助10
1秒前
田様应助幽默平安采纳,获得10
4秒前
可爱的函函应助刘小小123采纳,获得10
5秒前
瓣落的碎梦完成签到,获得积分0
7秒前
善学以致用应助momo采纳,获得10
8秒前
孝顺的觅风完成签到 ,获得积分10
8秒前
10秒前
刘小小123发布了新的文献求助10
13秒前
健壮的面包完成签到,获得积分10
13秒前
16秒前
孙燕应助科研界的恩希玛采纳,获得20
19秒前
20秒前
迷茫的一代完成签到,获得积分10
22秒前
量子星尘发布了新的文献求助10
22秒前
xingxingwang完成签到,获得积分10
23秒前
春来发布了新的文献求助30
24秒前
25秒前
25秒前
刘小小123完成签到,获得积分20
25秒前
xzy完成签到 ,获得积分10
26秒前
搜集达人应助无情向梦采纳,获得10
28秒前
阿伟1999发布了新的文献求助50
30秒前
momo发布了新的文献求助10
31秒前
li完成签到,获得积分10
32秒前
如此发布了新的文献求助10
34秒前
35秒前
赵静1234567890完成签到,获得积分10
35秒前
xxxllllll发布了新的文献求助10
39秒前
科研通AI2S应助科研通管家采纳,获得10
39秒前
Owen应助科研通管家采纳,获得10
39秒前
乐乐应助科研通管家采纳,获得10
39秒前
科研通AI5应助科研通管家采纳,获得10
39秒前
YamDaamCaa应助科研通管家采纳,获得50
39秒前
科研通AI5应助科研通管家采纳,获得10
39秒前
科目三应助科研通管家采纳,获得10
40秒前
爆米花应助科研通管家采纳,获得10
40秒前
稳重淇完成签到 ,获得积分10
40秒前
40秒前
41秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989334
求助须知:如何正确求助?哪些是违规求助? 3531428
关于积分的说明 11253936
捐赠科研通 3270119
什么是DOI,文献DOI怎么找? 1804887
邀请新用户注册赠送积分活动 882087
科研通“疑难数据库(出版商)”最低求助积分说明 809173