Catalytic reductive carbene transfer reactions

Efforts to develop catalytic carbene transfer reactions have largely relied on the use of diazo precursors. However, diazoalkanes are susceptible to undergoing violent exothermic decomposition unless they contain stabilizing substituents. Consequently, most synthetic methods are restricted to diazoacetates or related derivatives. In this Perspective, we describe an alternative approach to carbene transfer catalysis based on the generation of metal carbenoids from