虾青素
雨生红球菌
雅罗维亚
代谢工程
生物技术
发酵
生物过程
酵母
工业微生物学
工业生物技术
生物
生化工程
食品科学
工程类
生物化学
类胡萝卜素
酶
古生物学
作者
Mostafa Basiony,Liming Ouyang,Danni Wang,Jiaming Yu,Liming Zhou,Mohan Zhu,Xuyuan Wang,Jie Feng,Jing Dai,Yijie Shen,Chengguo Zhang,Qiang Hua,Xiuliang Yang,Lixin Zhang
标识
DOI:10.1016/j.synbio.2022.01.002
摘要
The global market demand for natural astaxanthin is rapidly increasing owing to its safety, the potential health benefits, and the diverse applications in food and pharmaceutical industries. The major native producers of natural astaxanthin on industrial scale are the alga Haematococcus pluvialis and the yeast Xanthopyllomyces dendrorhous. However, the natural production via these native producers is facing challenges of limited yield and high cost of cultivation and extraction. Alternatively, astaxanthin production via metabolically engineered non-native microbial cell factories such as Escherichia coli, Saccharomyces cerevisiae and Yarrowia lipolytica is another promising strategy to overcome these limitations. In this review we summarize the recent scientific and biotechnological progresses on astaxanthin biosynthetic pathways, transcriptional regulations, the interrelation with lipid metabolism, engineering strategies as well as fermentation process control in major native and non-native astaxanthin producers. These progresses illuminate the prospects of producing astaxanthin by microbial cell factories on industrial scale.
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