Full-bandwidth electrophysiology of seizures and epileptiform activity enabled by flexible graphene microtransistor depth neural probes

局部场电位 电生理学 神经科学 癫痫 微电极 发作性 多电极阵列 脑电图 神经活动 医学 生物医学工程 计算机科学 物理 心理学 电极 量子力学
作者
Andrea Bonaccini Calia,Eduard Masvidal‐Codina,Trevor Smith,Nathan Schäfer,Daman Rathore,Elisa Rodríguez-Lucas,Xavi Illa,Jose M. De la Cruz,Elena del Corro,Elisabet Prats‐Alfonso,Damià Viana,J Bousquet,Clément Hébert,Javier Martínez-Aguilar,Justin R. Sperling,Matthew Drummond,Arnab Halder,Abbie Dodd,Katharine Barr,Sinead Savage
出处
期刊:Nature Nanotechnology [Nature Portfolio]
卷期号:17 (3): 301-309 被引量:79
标识
DOI:10.1038/s41565-021-01041-9
摘要

Mapping the entire frequency bandwidth of brain electrophysiological signals is of paramount importance for understanding physiological and pathological states. The ability to record simultaneously DC-shifts, infraslow oscillations (<0.1 Hz), typical local field potentials (0.1-80 Hz) and higher frequencies (80-600 Hz) using the same recording site would particularly benefit preclinical epilepsy research and could provide clinical biomarkers for improved seizure onset zone delineation. However, commonly used metal microelectrode technology suffers from instabilities that hamper the high fidelity of DC-coupled recordings, which are needed to access signals of very low frequency. In this study we used flexible graphene depth neural probes (gDNPs), consisting of a linear array of graphene microtransistors, to concurrently record DC-shifts and high-frequency neuronal activity in awake rodents. We show here that gDNPs can reliably record and map with high spatial resolution seizures, pre-ictal DC-shifts and seizure-associated spreading depolarizations together with higher frequencies through the cortical laminae to the hippocampus in a mouse model of chemically induced seizures. Moreover, we demonstrate the functionality of chronically implanted devices over 10 weeks by recording with high fidelity spontaneous spike-wave discharges and associated infraslow oscillations in a rat model of absence epilepsy. Altogether, our work highlights the suitability of this technology for in vivo electrophysiology research, and in particular epilepsy research, by allowing stable and chronic DC-coupled recordings.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
村医发布了新的文献求助30
2秒前
2秒前
3秒前
Alandia发布了新的文献求助10
3秒前
Qing灿发布了新的文献求助10
3秒前
淡淡蛋挞发布了新的文献求助10
4秒前
优雅苑睐完成签到,获得积分10
4秒前
4秒前
陶醉延恶发布了新的文献求助10
5秒前
5秒前
5秒前
6秒前
wanci应助大神水瓶座采纳,获得10
6秒前
1235656646发布了新的文献求助10
6秒前
6秒前
彭洪泽发布了新的文献求助10
7秒前
FashionBoy应助狮子座采纳,获得10
8秒前
思源应助动听的母鸡采纳,获得10
8秒前
8秒前
8秒前
8秒前
爆米花应助俭朴的一曲采纳,获得10
8秒前
9秒前
9秒前
嗯哼发布了新的文献求助10
9秒前
10秒前
ccc完成签到 ,获得积分10
10秒前
阿九发布了新的文献求助10
11秒前
学术学习渣子完成签到,获得积分10
11秒前
Z6kjoA发布了新的文献求助20
11秒前
彭洪泽完成签到,获得积分10
12秒前
12秒前
HAHAHA发布了新的文献求助10
12秒前
刻苦冷菱发布了新的文献求助10
12秒前
12秒前
12秒前
13秒前
1235656646完成签到,获得积分10
13秒前
tyZhang完成签到,获得积分10
13秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3988732
求助须知:如何正确求助?哪些是违规求助? 3531027
关于积分的说明 11252281
捐赠科研通 3269732
什么是DOI,文献DOI怎么找? 1804764
邀请新用户注册赠送积分活动 881869
科研通“疑难数据库(出版商)”最低求助积分说明 809021