Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19

医学 2019-20冠状病毒爆发血栓形成肝素严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）冠状病毒疾病 2019年冠状病毒病（COVID-19）重症监护医学内科学传染病（医学专业）病毒学爆发

作者

Patrick R. Lawler,Ewan C. Goligher,Jeffrey S. Berger,Matthew D. Neal,Bryan J. McVerry,José Carlos Nicolau,Michelle N. Gong,Marc Carrier,Robert S. Rosenson,Harmony R. Reynolds,Alexis F. Turgeon,Jorge Escobedo,David T. Huang,Charlotte Bradbury,Brett L. Houston,Lucy Z. Kornblith,Anand Kumar,Susan R. Kahn,Mary Cushman,Zoe McQuilten,Arthur S. Slutsky,Keri S. Kim,Anthony Gordon,Bridget‐Anne Kirwan,Maria M. Brooks,Alisa Higgins,Roger J. Lewis,Elizabeth Lorenzi,Scott M. Berry,Lindsay R. Berry,Aaron W. Aday,Farah Al-Beidh,Djillali Annane,Yaseen M. Arabi,Diptesh Aryal,Lisa Baumann Kreuziger,Abi Beane,Zahra Bhimani,Shailesh Bihari,Henny H. Billett,Lindsay Bond,Marc J. M. Bonten,Frank M. Brunkhorst,Meredith Buxton,Adrian Buzgau,Lana A. Castellucci,Sweta Chekuri,Jen-Ting Chen,Allen Cheng,Tamta Chkhikvadze,Benjamin Coiffard,Todd W. Costantini,Sophie de Brouwer,Lennie Derde,Michelle A. Detry,Abhijit Duggal,Vladimír Džavík,Mark B. Effron,Lise J Estcourt,Brendan M. Everett,Dean Fergusson,Mark Fitzgerald,Robert Fowler,J.-P. Galanaud,Benjamin T. Galen,Sheetal Gandotra,Sebastián García-Madrona,Timothy D. Girard,Lucas C. Godoy,Andrew L. Goodman,Herman Goossens,Cameron Green,Yonatan Greenstein,Peter L. Gross,Naomi M. Hamburg,Rashan Haniffa,George P. Hanna,Nicholas Hanna,Sheila M. Hegde,Carolyn M. Hendrickson,R. Duncan Hite,Alexander Hindenburg,Aluko A. Hope,James Horowitz,Christopher M. Horvat,Kristin Hudock,Beverley J. Hunt,Mansoor Husain,Robert C. Hyzy,Vivek N. Iyer,Jeffrey R. Jacobson,Devachandran Jayakumar,Norma Keller,Akram Khan,Yuri Kim,Andrei Kindzelski,Andrew J King,M. Margaret Knudson,Aaron E. Kornblith,Vidya Krishnan,Matthew Kutcher,Michael Laffan,François Lamontagne,Grégoire Le Gal,Christine M. Leeper,Eric Leifer,George Lim,Felipe Gallego Lima,Kelsey Linstrum,Edward Litton,José López-Sendón,José Luis López-Sendón Moreno,Sylvain Lother,Saurabh Malhotra,Miguel Marcos,Andréa Saud Marinez,John C. Marshall,Nicole Marten,Michael A. Matthay,Daniel F McAuley,Emily G. McDonald,Anna McGlothlin,Shay McGuinness,Saskia Middeldorp,Stephanie K Montgomery,Steven C. Moore,Raquel Morillo Guerrero,Paul R Mouncey,Srinivas Murthy,Girish B. Nair,Rahul Nair,Alistair Nichol,Brenda Nunez‐Garcia,Ambarish Pandey,Pauline K. Park,Rachael Parke,Jane Parker,Sam Parnia,Jonathan Paul,Yessica S Pérez González,Mauricio Pompilio,Matthew E. Prekker,John G. Quigley,Natalia S. Rost,Kathy Rowan,Fernanda Oliveira dos Santos,Marlene Santos,Mayler Olombrada Nunes de Santos,Lewis Satterwhite,Christina Saunders,Roger E.G. Schutgens,Christopher W. Seymour,Deborah Siegal,Delcio G Silva,Manu Shankar-Hari,John P. Sheehan,Aneesh B. Singhal,Dayna Solvason,Simon Stanworth,Tobias Tritschler,Anne Turner,Wilma van Bentum-Puijk,Frank L. van de Veerdonk,Sean van Diepen,Gloria Vázquez-Grande,Lana Wahid,Vanessa Wareham,Bryan J. Wells,R. Jay Widmer,Jennifer G. Wilson,Eugene Yuriditsky,Fernando Godinho Zampieri,Derek C. Angus,Colin McArthur,Steven A R Webb,Michael E. Farkouh,Judith S. Hochman,Ryan Zarychanski

出处

期刊：The New England Journal of Medicine [New England Journal of Medicine]
日期：2021-08-26 卷期号：385 (9): 790-802 被引量：809

标识

DOI：10.1056/nejmoa2105911

摘要

Thrombosis and inflammation may contribute to the risk of death and complications among patients with coronavirus disease 2019 (Covid-19). We hypothesized that therapeutic-dose anticoagulation may improve outcomes in noncritically ill patients who are hospitalized with Covid-19.

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Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19

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