缺氧(环境)
病态的
白血病
生物
信号转导
缺氧诱导因子
癌症研究
医学
生物信息学
药理学
计算生物学
细胞生物学
化学
免疫学
内科学
生物化学
基因
有机化学
氧气
作者
Renfeng Xu,Fan Wang,Hongqin Yang,Zhengchao Wang
出处
期刊:Molecules
[MDPI AG]
日期:2022-05-26
卷期号:27 (11): 3426-3426
被引量:22
标识
DOI:10.3390/molecules27113426
摘要
Hypoxia-inducible factor-1α (HIF-1α) is widely distributed in human cells, and it can form different signaling pathways with various upstream and downstream proteins, mediate hypoxia signals, regulate cells to produce a series of compensatory responses to hypoxia, and play an important role in the physiological and pathological processes of the body, so it is a focus of biomedical research. In recent years, various types of HIF-1α inhibitors have been designed and synthesized and are expected to become a new class of drugs for the treatment of diseases such as tumors, leukemia, diabetes, and ischemic diseases. This article mainly reviews the structure and functional regulation of HIF-1α, the modes of action of HIF-1α inhibitors, and the application of HIF-1α inhibitors during the treatment of diseases.
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