嗜麦芽窄食单胞菌
微生物学
毒力
生物
抗生素
多重耐药
抗生素耐药性
生物膜
流出
病菌
鲍曼不动杆菌
铜绿假单胞菌
细菌
基因
遗传学
作者
Rikhia Majumdar,H. Karthikeyan,Vaishnavi Senthilnathan,Shobana Sugumar
出处
期刊:Recent Patents on Biotechnology
[Bentham Science]
日期:2022-12-01
卷期号:16 (4): 329-354
被引量:15
标识
DOI:10.2174/1872208316666220512121205
摘要
Stenotrophomonas maltophilia is an opportunistic pathogen that results in nosocomial infections in immunocompromised individuals. These bacteria colonize on the surface of medical devices and therapeutic equipment like urinary catheters, endoscopes, and ventilators, causing respiratory and urinary tract infections. The low outer membrane permeability of multidrug-resistance efflux systems and the two chromosomally encoded β- lactamases present in S. maltophilia are challenging for arsenal control. The cell-associated and extracellular virulence factors in S. maltophilia are involved in colonization and biofilm formation on the host surfaces. The spread of antibiotic-resistant genes in the pathogenic S. maltophilia attributes to bacterial resistance against a wide range of antibiotics, including penicillin, quinolones, and carbapenems. So far, tetracycline derivatives, fluoroquinolones, and trimethoprim-sulfamethoxazole (TMP-SMX) are considered promising antibiotics against S. maltophilia. Due to the adaptive nature of the intrinsically resistant mechanism towards the number of antibiotics and its ability to acquire new resistance via mutation and horizontal gene transfer, it is quite tricky for medicinal contribution against S. maltophilia. The current review summarizes the literary data on pathogenicity, quorum sensing, biofilm formation, virulence factors, and antibiotic resistance of S. maltophilia.
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