光热治疗
光子上转换
MXenes公司
光动力疗法
光敏剂
荧光
纳米技术
材料科学
纳米医学
纳米颗粒
聚集诱导发射
荧光寿命成像显微镜
化学
光化学
光电子学
发光
光学
有机化学
物理
作者
Yuanwei Wang,Niu Niu,Yang Huang,Shanliang Song,Hui Tan,Lei Wang,Dong Wang,Ben Zhong Tang
标识
DOI:10.1002/smtd.202200393
摘要
Abstract Inspired by the excellent photothermal conversion ability and inherent nanomedicine platform property of MXenes, efficient reactive oxygen species production and prominent fluorescence emission feature of aggregation‐induced emission (AIE)‐active photosensitizers (PSs), as well as the extending excitation wavelength capability of upconversion nanoparticles (UCNPs), a versatile nanoplatform comprised of Ti 3 C 2 nanosheets (NSs), AIE‐active PSs and UCNPs is intelligently fabricated. This three‐pronged strategy takes advantages of each component simultaneously, and realizes fluorescence imaging/photoacoustic imaging/photothermal imaging triple‐modal imaging‐guided photothermal/photodynamic synergetic therapy under 808 nm laser irradiation. The introduction of UCNPs actualizes the long wavelength‐activation of AIE‐active PSs, which significantly increases the tissue penetration depth. Spatially isolation of AIE‐active PSs and Ti 3 C 2 NSs is beneficial for suppressing the fluorescence quenching effect of Ti 3 C 2 NSs, bringing about ultimately brilliant fluorescence. The covalently bonded polymer surface endows the nanoplatform with excellent physiological stability and efficient tumor accumulation. These outputs reveal a win‐win cooperation of multiple inorganic/organic nanocomposites for phototheranostics, and present great potential for future clinical translations.
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