A fish-scale derived multifunctional nanofiber membrane for infected wound healing

The rapid development of modern medicine has put forward new requirements for wound infection healing methods in clinical treatment. Despite the great achievements made in the research and development of various types of dressings in recent years, yet there is still a challenge of multifunctional dressings for effective wound treatment. Herein, a multifunctional nanofibrous membrane was prepared by encapsulating NIR-adsorbed CuS (FSC/CuS) nanoparticles, polyvinylpyrrolidone (PVP) and polyvinyl butyral (PVB) with electrospun fish scale collagen. During the evaluation of wound healing, four parameters, including hemostasis time, inflammatory response, cell proliferation, and tissue remodeling, were considered. The results of H&E, Masson and immunohistochemical staining showed that the synergistic effect of composite nanofibers and near-infrared light can inhibit the inflammatory response, promote the proliferation and migration of fibroblasts and keratinocytes, rebuild new tissues, form well-dispersed collagen fibers, etc. It was shown that the FSC/CuS NPs combined with an NIR-driven experimental group exhibited excellent performance in accelerating wound healing in these stages. This kind of nanofibrous scaffold prepared with fish scale and NIR-absorbing agents will have broad application prospects in the healing of infected wounds.