Conditional GANs based system for fibrosis detection and quantification in Hematoxylin and Eosin whole slide images

计算机科学 H&E染色 人工智能 数字化病理学 污渍 三色 分割 管道(软件) 病理 马森三色染色 深度学习 纤维化 模式识别(心理学) 计算机视觉 医学 染色 程序设计语言
作者
Ahmed M. Naglah,Fahmi Khalifa,Ayman El‐Baz,Dibson Gondim
出处
期刊:Medical Image Analysis [Elsevier BV]
卷期号:81: 102537-102537 被引量:11
标识
DOI:10.1016/j.media.2022.102537
摘要

Assessing the degree of liver fibrosis is fundamental for the management of patients with chronic liver disease, in liver transplants procedures, and in general liver disease research. The fibrosis stage is best assessed by histopathologic evaluation, and Masson's Trichrome stain (MT) is the stain of choice for this task in many laboratories around the world. However, the most used stain in histopathology is Hematoxylin Eosin (HE) which is cheaper, has a faster turn-around time and is the primary stain routinely used for evaluation of liver specimens. In this paper, we propose a novel digital pathology system that accurately detects and quantifies the footprint of fibrous tissue in HE whole slide images (WSI). The proposed system produces virtual MT images from HE using a deep learning model that learns deep texture patterns associated with collagen fibers. The training pipeline is based on conditional generative adversarial networks (cGAN), which can achieve accurate pixel-level transformation. Our comprehensive training pipeline features an automatic WSI registration algorithm, which qualifies the HE/MT training slides for the cGAN model. Using liver specimens collected during liver transplantation procedures, we conducted a range of experiments to evaluate the detected footprint of selected anatomical features. Our evaluation includes both image similarity and semantic segmentation metrics. The proposed system achieved enhanced results in the experiments with significant improvement over the state-of-the-art CycleGAN learning style, and over direct prediction of fibrosis in HE without having the virtual MT step.
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