Evaluation of PPAR-γ with lipid profiles and blood glucose in obese persons with DM type 2 and obese persons without DM type 2

PPAR-γ is expressed at high levels in adipose tissue and is a central regulator of adipocyte gene expression and differentiation. PPAR-γ is induced during adipocyte differentiation, and retroviral expression of PPAR-γ stimulates adipose differentiation of cultured fibroblasts. Several studies demonstrate that PPAR-γ is both necessary and sufficient to promote differentiation of fat cells both in vivo and in vitro. The present study has been conducted at the Department of Biochemistry, Shri Ram Murti Smark Institute of Medical Sciences (SRMS IMS), Bareilly U.P. India. Among 30 Adult normal persons, 30 Adult obese persons without DM type 2 and 30 Adult obese persons with DM type 2 were selected for the study. BMI was measured for each subject and proposed biochemical parameters were estimated in their blood samples. The Subject chosen were not on any drug treatment during days of blood collection. Age of the subject was between 25-65 years. For the present study 30 normal (control) and 60 obese cases were taken. Out of 60 obese cases, 30 were found to be without DM Type-2 and 30 cases with DM Type-2.