小RNA
DNA甲基化
生物
计算生物学
基因
甲基化
基因表达
表观遗传学
基因表达调控
遗传学
细胞生物学
作者
Zarrin Banikazemi,Mojgan Farshadi,Ali Rajabi,Mina Homayoonfal,Nasrin Sharifi,Reza Sharafati Chaleshtori
出处
期刊:Chemosphere
[Elsevier]
日期:2022-12-01
卷期号:308: 136299-136299
被引量:6
标识
DOI:10.1016/j.chemosphere.2022.136299
摘要
When plastic objects in our surroundings are degraded, they may produce particles ranging in size from 1 to 100 nm therefore called nanoplastics. The environmental chemicals including nanoplastics may be able to affect biological processes in the nuclear level like altering DNA methylation and regulating microRNAs (miRNAs) as well as long non-coding RNAs (lncRNAs) expression and therefore are implicated in chronic human diseases like neoplasms. The regulatory role of miRNAs and lncRNAs in gene expression is appreciated. In vitro as well as in vivo experiments have shown that environmental elements including nanoplastics are able to dysregulate miRNAs and lncRNAs expression with possible genetic consequences that increase the risk of cancer development. In the current article, we review the biological effects of miRNAs and lncRNAs alterations following nanoplastics exposure.
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