Effectiveness of Negative Pressure Wound Therapy of Diabetic Foot Ulcers Using Periplaneta Americana (Kangfuxin Liquid) Irrigation

医学 糖尿病足 负压伤口治疗 外科 大蠊 脚(韵律) 糖尿病溃疡 糖尿病 皮肤病科 病理 哲学 内分泌学 替代医学 蟑螂 生物 语言学 生态学
作者
Haojie Sun,Chengxin Yang,Xuekui Liu,Jun Liang,Houfa Geng
出处
期刊:The International Journal of Lower Extremity Wounds [SAGE Publishing]
被引量:4
标识
DOI:10.1177/15347346231176917
摘要

This study was to evaluate the efficacy of Periplaneta Americana (Kangfuxin Liquid) relative to normal saline when applied in negative-pressure wound therapy (NPWT) with instillation for facilitating diabetic foot ulcers (DFUs) healing. Eighty patients with Wagner grades 3 or 4 DFUs were enrolled in this retrospective study. Based on the treatment type, patients were equally assigned to either (i) an NPWT with Kangfuxin liquid instillation group (NPWT-K) or (ii) an NPWT with normal saline instillation group (NPWT-I). The primary study outcome was the wound healing rate and Kaplan-Meier survival estimate was used to examine the cumulative wound healing rate, while the secondary outcomes were the amputation rate, inpatient days, duration of antibiotic treatments, reinfection rate, new ulcer formation rate, readmission rate, and changes in the inflammatory markers (such as ESR, CRP, and PCT) and serum growth factors (including VEGF, EGF, and bFGF). The 12-week wound healing rate (31 of 40[77.5%] vs 22 of 40[55.0%], P = .033) and the cumulative wound healing rate was higher in the NPWT-K group than in the NPWT-I group (P = .004). The wound healing time was shorter in the NPWT-K group (55 days [95% CI 50-60]) than in the NPWT-K group (64 days [95% CI 59-69], P = .016). Patients who received NPWT-K had fewer inpatient days and duration of antibiotic treatment and faced lower reinfection and readmission rates (P < .05). After 1 week of treatment, the ESR, CRP, and PCT levels in the blood were lower in the NPWT-K group than in the NPWT-I group (P < .05), while the VEGF, EGF, and bFGF levels in the NPWT-K group were higher than those in the NPWT-I group (P < .001). The present study showed that NPWT with Kangfuxin liquid instillation was effective and showed significantly accelerated DFUs healing. Thus, Kangfuxin liquid is an effective instillation solution for use in the treatment of DFUs with NPWT.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
拔草学士发布了新的文献求助10
2秒前
3秒前
young完成签到,获得积分10
5秒前
徐徐完成签到,获得积分10
5秒前
中西西完成签到 ,获得积分10
7秒前
华仔应助sxhdxwf采纳,获得30
9秒前
奋斗的怀曼完成签到,获得积分10
9秒前
10秒前
10秒前
13秒前
14秒前
14秒前
loong发布了新的文献求助10
15秒前
莫挽完成签到,获得积分10
15秒前
15秒前
16秒前
16秒前
小垃圾完成签到,获得积分10
17秒前
YHT完成签到,获得积分10
17秒前
万能图书馆应助loong采纳,获得10
19秒前
今后应助leonzhou采纳,获得10
19秒前
3080发布了新的文献求助20
20秒前
拖把粘十发布了新的文献求助10
21秒前
22秒前
23秒前
23秒前
Jasper应助芝士奶盖有点咸采纳,获得10
24秒前
24秒前
liiiii发布了新的文献求助10
25秒前
liiiii发布了新的文献求助10
27秒前
liiiii发布了新的文献求助10
27秒前
JamesPei应助认真跳跳糖采纳,获得10
27秒前
28秒前
liiiii发布了新的文献求助10
28秒前
张雯思发布了新的文献求助10
28秒前
WK完成签到,获得积分10
29秒前
29秒前
Muhammad发布了新的文献求助10
30秒前
FashionBoy应助Karol采纳,获得10
32秒前
Michelangelo_微风完成签到,获得积分10
32秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989711
求助须知:如何正确求助?哪些是违规求助? 3531864
关于积分的说明 11255235
捐赠科研通 3270505
什么是DOI,文献DOI怎么找? 1804983
邀请新用户注册赠送积分活动 882157
科研通“疑难数据库(出版商)”最低求助积分说明 809176