Research Progress of Naphthalimide Derivatives Optical Probes for Monitoring Physical and Chemical Properties of Microenvironment and Active Sulfur Substances

Naphthalimide derivatives have been designed as optical probes and applied in various biological scenarios due to their excellent photophysical properties.As an important microenvironment and active sulfur substance in biology plays an important role in biological system, it is necessary to detect it efficiently.The detection of naphthalimide derivatives for microenvironment and active sulfur substances is reviewed.The detection of microenvironment is described from four aspects of pH value, viscosity, polarity and temperature, and the design scheme of the probe and the comparison of all kinds of fluorescence properties are discussed.From the point of view of detection strategy, the mechanism is divided into nucleophilic substitution strategy, nucleophilic addition strategy, substituent reduction strategy, heavy metal replacement strategy and other strategies, and the fluorescence properties of these probes are summarized and compared.Finally, some shortcomings in the design and practical application of this kind of probe are described, and the future prospect of this field is prospected.