生物发生
细胞生物学
GTP酶
生物
效应器
纤毛形成
小泡
小型GTPase
纤毛
信号转导
生物化学
基因
膜
作者
Fulong Li,Kun‐Liang Guan
出处
期刊:BioEssays
[Wiley]
日期:2023-03-30
卷期号:45 (6)
被引量:2
标识
DOI:10.1002/bies.202200214
摘要
The Arf family proteins are best known for their roles in the vesicle biogenesis. However, they also play fundamental roles in a wide range of cellular regulation besides vesicular trafficking, such as modulation of lipid metabolic enzymes, cytoskeleton remodeling, ciliogenesis, lysosomal, and mitochondrial morphology and functions. Growing studies continue to expand the downstream effector landscape of Arf proteins, especially for the less-studied members, revealing new biological functions, such as amino acid sensing. Experiments with cutting-edge technologies and in vivo functional studies in the last decade help to provide a more comprehensive view of Arf family functions. In this review, we summarize the cellular functions that are regulated by at least two different Arf members with an emphasis on those beyond vesicle biogenesis.
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