核运输
核质
机制(生物学)
细胞质
核孔
核孔蛋白
核出口信号
转运蛋白
核心
细胞核
细胞生物学
核蛋白
细胞器
计算生物学
生物
化学
遗传学
核仁
基因
物理
转录因子
量子力学
作者
Zhaoxia Sun,Zhi Peng Fan
出处
期刊:PubMed
日期:2024-03-28
卷期号:27 (1): 39-46
标识
DOI:10.3290/j.cjdr.b5136729
摘要
Coordination and information exchange among the various organelles ensure the precise and orderly functioning of eukaryotic cells. Interaction between the cytoplasm and nucleoplasm is crucial for many physiological processes. Macromolecular protein transport into the nucleus requires assistance from the nuclear transport system. These proteins typically contain a nuclear localisation sequence that guides them to enter the nucleus. Understanding the mechanism of nuclear import of macromolecular proteins is important for comprehending cellular processes. Investigation of disease-related alterations can facilitate the development of novel therapeutic strategies and provide additional evidence for clinical trials. This review provides an overview of the proteins involved in nuclear transport and the mechanisms underlying macromolecular protein transport.
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