Long-term exposure to major constituents of fine particulate matter and neurodegenerative diseases: A population-based survey in the Pearl River Delta Region, China

四分位数 优势比 环境卫生 医学 人口 微粒 置信区间 化学 内科学 有机化学
作者
Qi-Zhen Wu,Hui-Xian Zeng,John Andersson,Anna Oudin,Katja M. Kanninen,Mu-Wu Xu,Shuang-Jian Qin,Qixian Zeng,Bin Zhao,Mei Zheng,Nanxiang Jin,Wei-Chun Chou,Pasi Jalava,Guang‐Hui Dong,Xiao‐Wen Zeng
出处
期刊:Journal of Hazardous Materials [Elsevier BV]
卷期号:470: 134161-134161 被引量:1
标识
DOI:10.1016/j.jhazmat.2024.134161
摘要

Exposure to PM2.5 has been linked to neurodegenerative diseases, with limited understanding of constituent-specific contributions. To explore the associations between long-term exposure to PM2.5 constituents and neurodegenerative diseases. We recruited 148,274 individuals aged ≥ 60 from four cities in the Pearl River Delta region, China (2020 to 2021). We calculated twenty-year average air pollutant concentrations (PM2.5 mass, black carbon (BC), organic matter (OM), ammonium (NH4+), nitrate (NO3-) and sulfate (SO42-)) at the individuals' home addresses. Neurodegenerative diseases were determined by self-reported doctor-diagnosed Alzheimer's disease (AD) and Parkinson's disease (PD). Generalized linear mixed models were employed to explore associations between pollutants and neurodegenerative disease prevalence. PM2.5 and all five constituents were significantly associated with a higher prevalence of AD and PD. The observed associations generally exhibited a non-linear pattern. For example, compared with the lowest quartile, higher quartiles of BC were associated with greater odds for AD prevalence (i.e., the adjusted odds ratios were 1.81; 95% CI, 1.45-2.27; 1.78; 95% CI, 1.37-2.32; and 1.99; 95% CI, 1.54-2.57 for the second, third, and fourth quartiles, respectively). Long-term exposure to PM2.5 and its constituents, particularly combustion-related BC, OM, and SO42-, was significantly associated with higher prevalence of AD and PD in Chinese individuals. PM2.5 is a routinely regulated mixture of multiple hazardous constituents that can lead to diverse adverse health outcomes. However, current evidence on the specific contributions of PM2.5 constituents to health effects is scarce. This study firstly investigated the association between PM2.5 constituents and neurodegenerative diseases in the moderately to highly polluted Pearl River Delta region in China, and identified hazardous constituents within PM2.5 that have significant impacts. This study provides important implications for the development of targeted PM2.5 prevention and control policies to reduce specific hazardous PM2.5 constituents.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
JayeChen发布了新的文献求助100
刚刚
社牛小柯发布了新的文献求助10
1秒前
2秒前
大个应助张浩采纳,获得10
3秒前
南巷完成签到,获得积分10
3秒前
4秒前
4秒前
ED应助虚幻靖易采纳,获得10
4秒前
李爱国应助淡淡梦容采纳,获得10
5秒前
lalala发布了新的文献求助10
5秒前
南巷发布了新的文献求助10
6秒前
Jasper应助时尚初南采纳,获得10
6秒前
courage完成签到,获得积分10
7秒前
搜集达人应助祖安露采纳,获得10
8秒前
善学以致用应助小周周采纳,获得10
8秒前
GXLong发布了新的文献求助10
9秒前
Hey发布了新的文献求助20
9秒前
9秒前
10秒前
柯米克发布了新的文献求助10
10秒前
lm发布了新的文献求助10
13秒前
CipherSage应助体贴汽车采纳,获得10
15秒前
两味愚发布了新的文献求助10
15秒前
16秒前
18秒前
小马甲应助GXLong采纳,获得10
18秒前
18秒前
CodeCraft应助柯米克采纳,获得10
18秒前
深情安青应助淡淡梦容采纳,获得10
19秒前
苏利文发布了新的文献求助30
20秒前
JayeChen完成签到,获得积分10
20秒前
20秒前
屈绮兰应助张张采纳,获得30
21秒前
ding应助玉小赤采纳,获得10
21秒前
22秒前
愉快的雪珍完成签到,获得积分10
23秒前
sylnd126发布了新的文献求助10
23秒前
23秒前
KK发布了新的文献求助10
24秒前
25秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3988732
求助须知:如何正确求助?哪些是违规求助? 3531027
关于积分的说明 11252281
捐赠科研通 3269732
什么是DOI,文献DOI怎么找? 1804764
邀请新用户注册赠送积分活动 881869
科研通“疑难数据库(出版商)”最低求助积分说明 809021