Association of early-life exposure to air and noise pollution with youth mental health: findings from the ALSPAC cohort

怀孕 纵向研究 混淆 萧条(经济学) 千年队列研究(美国) 医学 优势比 环境卫生 心理健康 可能性 空气污染 队列研究 人口学 逻辑回归 精神科 遗传学 内科学 生物 化学 有机化学 经济 社会学 病理 宏观经济学
作者
Joanne B. Newbury,Jon Heron,James B. Kirkbride,Andy Boyd,Richard Thomas,Stanley Zammit,Helen L. Fisher,Ioannis Bakolis
出处
期刊:The Lancet Planetary Health [Elsevier BV]
卷期号:8: S11-S11
标识
DOI:10.1016/s2542-5196(24)00076-7
摘要

BackgroundIncreasing evidence suggests that air pollution exposure contributes to the development of mental health problems, including psychosis and depression. However, little is known about the importance of early-life exposure, nor the potential role of noise pollution, a correlate of air pollution. We examined the association of exposure to air and noise pollution from pregnancy to age 12 years with three mental health problems assessed at ages 12, 18, and 24 years.MethodsData were from the Avon Longitudinal Study of Parents and Children (ALSPAC), which tracks the development of about 14 000 babies who had expected delivery dates between April 1, 1991, and Dec 31, 1992, in Avon, UK. This was linked with novel data on nitrogen dioxide, PM2·5, and noise pollution in pregnancy, childhood (ages 1–9 years), and adolescence (ages 10–12 years). Psychotic experiences, depression, and anxiety were measured at ages 12, 18, and 24 years. Logistic regression models were controlled for individual-level, family-level, and area-level confounders, and e-values were calculated to estimate residual confounding.FindingsParticipants exposed to higher PM2.5, particularly during pregnancy, had greater odds for psychotic experiences (adjusted odds ratio 1·17 [95% CI 1·05–1·30]) and depression (1·11 [1·01–1·22]). There was little evidence associating nitrogen dioxide or noise pollution with psychotic experiences or depression. Conversely, higher nitrogen dioxide (but not PM2·5) exposure in pregnancy (1·16 [1·01–1·33]), and higher noise pollution in childhood (1·20 [1·06-1·37]) and adolescence (1·17 [1·02-1·35]), were associated with greater odds for anxiety.InterpretationOur study builds on evidence linking air pollution to psychosis and depression and provides rare longitudinal evidence linking noise pollution to anxiety. Our findings indicate that air pollution exposure earlier in development (eg, during pregnancy) might be particularly important, and suggest a degree of specificity in terms of pollutant-outcome associations. If causal, our findings suggest that interventions to reduce air pollution would improve global mental health.FundingWellcome Trust, UK Medical Research Council–Wellcome, and University of Bristol.
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