褐藻糖胶
水泡藻
内部收益率3
甘露糖
坦克结合激酶1
岩藻糖
化学
褐藻
生物化学
阿拉伯糖
多糖
半乳糖
木糖
生物
信号转导
蛋白激酶B
先天免疫系统
植物
藻类
受体
发酵
MAP激酶激酶激酶
作者
Chuanqin Shi,Shihua Zhao,Liyan Mi,Deying Niu,Fanwen Hu,Wenwei Han,Bing Li
标识
DOI:10.1016/j.ijbiomac.2024.131336
摘要
Fucoidan, a sulfated polysaccharide of marine origin found in brown algae and sea cucumbers, has been identified as a neuroprotective compound. In this study, a novel fucoidan MF4 was extracted from Fucus vesiculosus and isolated using Q-Sepharose fast-flow ion-exchange chromatography. The physicochemical properties of MF4 were characterized. MF4 is primarily composed of fucose, xylose, galactose, glucose, and mannose in a molar ratio of 12.3: 4.9: 1.1: 1.0: 1.1, with an average molecular weight of 67.7 kDa. Notably, MF4 demonstrated suppression of LLC tumor growth in vivo. RNA-sequencing analysis revealed that MF4 enhanced the expression of type I interferon–associated downstream genes in macrophages. Furthermore, MF4 increased the levels of phosphorylated TBK1 and IRF3 proteins in vitro. By activating the STING–TBK1–IRF3 signaling pathway, MF4 may enhance the antitumor activity of macrophages. Taken together, MF4 has promising potential as an antitumor and immunomodulatory agent.
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