内质网
生物
神经退行性变
细胞生物学
果蝇属(亚属)
降级(电信)
运输机
生物化学
基因
内科学
疾病
计算机科学
医学
电信
作者
Xiaoran Guo,Morgan Mutch,Alba Yurani Torres,Denise J. Montell,Nishi Rauth,Jacob Harwood,Drew McDonald,Zijing Chen,Craig Montell,Wei Dai,Denise J. Montell
标识
DOI:10.1016/j.devcel.2024.04.003
摘要
Proteotoxic stress drives numerous degenerative diseases. Cells initially adapt to misfolded proteins by activating the unfolded protein response (UPR), including endoplasmic-reticulum-associated protein degradation (ERAD). However, persistent stress triggers apoptosis. Enhancing ERAD is a promising therapeutic approach for protein misfolding diseases. The ER-localized Zn
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