面筋
疾病
基因
免疫学
医学
生物
遗传学
病理
作者
Valérie Abadie,Arnold Han,Bana Jabrì,Ludvig M. Sollid
标识
DOI:10.1053/j.gastro.2024.03.042
摘要
Celiac disease (CeD) is a gluten-induced enteropathy that develops in genetically susceptible individuals upon consumption of cereal gluten proteins. It is a unique and complex immune disorder to study as the driving antigen is known and the tissue targeted by the immune reaction can be interrogated. This review integrates findings gained from genetic, biochemical, and immunologic studies, which together have revealed mechanisms of gluten peptide modification and HLA binding, thereby enabling a maladapted anti-gluten immune response. Observations in human samples combined with experimental mouse models have revealed that the gluten-induced immune response involves CD4
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