Quantitative assessment of abdominal ectopic fat deposits in patients with different glucose tolerance by using mDixon Quant MRI

腹部脂肪 定量评估 医学 核医学 内科学 体重 风险分析(工程)
作者
Bo Yuan,Zhengzheng Tao,Yajie Ma,Yuling Zhang,Zhiqiang Chu,Ji Qian
出处
期刊:Scientific Reports [Nature Portfolio]
卷期号:15 (1)
标识
DOI:10.1038/s41598-025-92004-w
摘要

This study aimed to quantitatively analyze the characteristics of abdominal ectopic fat deposition in patients with different glucose tolerance by using mDixon Quant MRI. A total of 98 patients and 38 healthy volunteers were included in this study. The patients were stratified as impaired glucose tolerance (IGT) group (n = 18), the duration of diabetes less than 5 years (DMa group, n = 31) and longer than 5 years(DMb group, n = 49). The fat fraction (FF) of left hepatic lobe, right hepatic lobe, whole liver, pancreatic head, pancreatic body, pancreatic tail, spleen, kidney, as well as L3 vertebra, psoas muscle, the total abdominal fat area(S1), intra-abdominal fat area (S2) and S3 (S2/S1) were measured and calculated separately. Analysis of variance, correlation analysis, paired sample t-test, Welch's ANOVA, ROC curve and ordered multivariate logistic regression were performed for statistical analyses. The difference in BMI and weight among the four groups were statistically significant (P < 0.001). The metabolic parameters were statistically significant among three patients groups (P < 0.05). The differences in FF values of left hepatic lobe, right hepatic lobe and whole liver, spleen, pancreatic head, pancreatic body and pancreatic tail, L3 vertebra, psoas muscle, S1, S2 and S3 were statistically significant among the four groups (P < 0.001). The FF values of L3 vertebra and the pancreatic tail had the higher diagnostic efficacy when assessing the presence and extent of impaired glucose tolerance, respectively. For each percentile increased in the FF value of the L3 vertebra, the risk of diabetes entering the next stage increases 16%. Different organs in the abdomen have different sensitivity to fat deposition. The liver and pancreas have uneven distribution of fat deposits in people with different glucose tolerance. However, ectopic fat deposition do not change significantly with the duration of the disease. The FF value of L3 vertebra is a sensitive imaging index in patients with different glucose tolerance.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
八八九九九1完成签到,获得积分10
1秒前
tigger完成签到 ,获得积分10
2秒前
4秒前
6秒前
优雅的千雁完成签到,获得积分10
8秒前
2316690509完成签到 ,获得积分10
8秒前
没用的三轮完成签到,获得积分10
8秒前
fancy完成签到 ,获得积分10
8秒前
mayberichard完成签到,获得积分10
12秒前
LINDENG2004完成签到 ,获得积分10
18秒前
wz完成签到,获得积分10
19秒前
简奥斯汀完成签到 ,获得积分10
26秒前
五本笔记完成签到 ,获得积分10
26秒前
29秒前
花花发布了新的文献求助20
29秒前
asd113发布了新的文献求助10
33秒前
美满的小蘑菇完成签到 ,获得积分10
33秒前
自然白安完成签到 ,获得积分10
39秒前
量子星尘发布了新的文献求助10
42秒前
等待小鸽子完成签到 ,获得积分10
44秒前
龙虾发票完成签到,获得积分10
51秒前
小康学弟完成签到 ,获得积分10
51秒前
了0完成签到 ,获得积分10
51秒前
慕青应助科研通管家采纳,获得10
54秒前
彭于晏应助科研通管家采纳,获得30
54秒前
毛豆爸爸应助科研通管家采纳,获得20
54秒前
林利芳完成签到 ,获得积分0
55秒前
JaneChen完成签到 ,获得积分10
57秒前
健壮惋清完成签到 ,获得积分10
57秒前
58秒前
gabee完成签到 ,获得积分10
1分钟前
liang19640908完成签到 ,获得积分10
1分钟前
奋斗的雪曼完成签到 ,获得积分10
1分钟前
粗心的飞槐完成签到 ,获得积分10
1分钟前
LELE完成签到 ,获得积分10
1分钟前
了0完成签到 ,获得积分10
1分钟前
apocalypse完成签到 ,获得积分10
1分钟前
guhao完成签到 ,获得积分10
1分钟前
指导灰完成签到 ,获得积分10
1分钟前
善良的火完成签到 ,获得积分10
1分钟前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038066
求助须知:如何正确求助?哪些是违规求助? 3575779
关于积分的说明 11373801
捐赠科研通 3305584
什么是DOI,文献DOI怎么找? 1819239
邀请新用户注册赠送积分活动 892655
科研通“疑难数据库(出版商)”最低求助积分说明 815022