嗅球
生物
星形胶质细胞
神经科学
组蛋白
神经递质
细胞生物学
生物化学
基因
中枢神经系统
作者
Debosmita Sardar,Yi-Ting Cheng,Junsung Woo,Dong‐Joo Choi,Zhung-Fu Lee,Wookbong Kwon,Hsiao‐Chi Chen,Brittney Lozzi,Alexis Cervantes,Kavitha Rajendran,Teng-Wei Huang,Antrix Jain,Benjamin R. Arenkiel,Ian Maze,Benjamin Deneen
出处
期刊：Science
[American Association for the Advancement of Science]
日期：2023-06-15
卷期号：380 (6650)
被引量：26
标识
DOI：10.1126/science.ade0027
摘要
Neuronal activity drives alterations in gene expression within neurons, yet how it directs transcriptional and epigenomic changes in neighboring astrocytes in functioning circuits is unknown. We found that neuronal activity induces widespread transcriptional up-regulation and down-regulation in astrocytes, highlighted by the identification of
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