Maternal exposure to neonicotinoid insecticides and fetal growth restriction: A nested case-control study in the guangxi Zhuang birth cohort

胎儿生长 医学 产前暴露 套式病例对照研究 新烟碱 队列 怀孕 队列研究 毒理 产科 环境卫生 胎儿 生物 内科学 杀虫剂 益达胺 妊娠期 遗传学 农学
作者
Dongxiang Pan,Mengrui Lin,Changhui Mu,Chuanxiang Yu,Bowen Ye,Jun Liang,Yonghong Sheng,Dongping Huang,Shun Liu,Xiaoyun Zeng,Hui Juan Jennifer Tan,Virasakdi Chongsuvivatwong,Xiaoqiang Qiu
出处
期刊:Chemosphere [Elsevier BV]
卷期号:336: 139217-139217 被引量:13
标识
DOI:10.1016/j.chemosphere.2023.139217
摘要

Fetal growth restriction (FGR) is a major determinant of perinatal morbidity and mortality, with adverse long-term neurocognitive effects in childhood and adulthood. Prenatal exposure to environmental pollutants has been reported to be associated with FGR. Neonicotinoids (NEOs) are extensively used insecticides worldwide and are suggested to have embryonic and developmental neurotoxicity. However, the effects of NEOs exposure on FGR is unknown.We aimed to quantify the single and combined associations of maternal exposure to NEOs and FGR.We conducted a nested case-control study based on the Guangxi Zhuang Birth Cohort, China. A total of 387 with FGR cases and 1096 without- FGR controls were included between 2015 and 2018. Ten NEOs were measured by UPLC-MS from the maternal blood samples were pre-collected in the first trimester. After adjusting for potential confounders, multivariable logistic regressions, weighted quantile sum regression and quantile g-computation were performed for individual and NEOs mixtures.In the individual exposure models, each 1-standard deviation increment of the natural-log in dinotefuran and acetamiprid concentrations were significantly associated with odds ratios of 1.93 (95% CI: 1.69, 2.20) and 1.31 (95% CI: 1.07, 1.59) higher odds of FGR, respectively. However, the FGR risk was negatively associated with thiacloprid, sulfoxaflor, and nitenpyram (OR = 0.23, 95%CI: 0.15, 0.34; OR = 0.48, 95%CI: 0.41, 0.56; OR = 0.86, 95%CI: 0.80, 0.93; respectively). Similar findings were found in the combined exposure analysis. Dinotefuran was the most strongly attributable to increase FGR, while sulfoxaflor and thiacloprid contributed the highest negative weighted on FGR. Furthermore, each quintile increase in all ten NEOs exposures was associated with FGR (OR = 0.21, 95% CI: 0.08, 0.54).Our findings suggest that maternal single and combined exposures to NEOs were associated with varying FGR risks. They contribute to the mounting evidence on serum NEOs exposure impact on FGR. However, a replication of these associations in other populations is warranted.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
林利芳完成签到 ,获得积分0
刚刚
JaneChen完成签到 ,获得积分10
2秒前
健壮惋清完成签到 ,获得积分10
2秒前
3秒前
gabee完成签到 ,获得积分10
7秒前
liang19640908完成签到 ,获得积分10
10秒前
奋斗的雪曼完成签到 ,获得积分10
16秒前
粗心的飞槐完成签到 ,获得积分10
16秒前
LELE完成签到 ,获得积分10
23秒前
了0完成签到 ,获得积分10
24秒前
apocalypse完成签到 ,获得积分10
29秒前
guhao完成签到 ,获得积分10
30秒前
指导灰完成签到 ,获得积分10
30秒前
善良的火完成签到 ,获得积分10
41秒前
优雅夕阳完成签到 ,获得积分10
43秒前
Jasper应助光亮的自行车采纳,获得10
43秒前
miki完成签到,获得积分10
44秒前
量子星尘发布了新的文献求助10
45秒前
糖宝完成签到 ,获得积分10
52秒前
KX2024完成签到,获得积分10
55秒前
松松发布了新的文献求助20
58秒前
nusiew完成签到,获得积分10
58秒前
huiluowork完成签到 ,获得积分10
59秒前
陶醉的翠霜完成签到 ,获得积分10
59秒前
59秒前
冷静如松完成签到 ,获得积分10
1分钟前
1分钟前
浮云完成签到 ,获得积分10
1分钟前
屈岂愈完成签到,获得积分10
1分钟前
1分钟前
Pupil完成签到,获得积分10
1分钟前
偏偏意气用事完成签到,获得积分10
1分钟前
安安完成签到,获得积分10
1分钟前
cttc完成签到,获得积分10
1分钟前
Chnimike完成签到 ,获得积分10
1分钟前
1分钟前
红茸茸羊完成签到 ,获得积分10
1分钟前
年轻千愁完成签到 ,获得积分10
1分钟前
liu完成签到,获得积分10
1分钟前
量子星尘发布了新的文献求助10
1分钟前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038066
求助须知:如何正确求助?哪些是违规求助? 3575779
关于积分的说明 11373801
捐赠科研通 3305584
什么是DOI,文献DOI怎么找? 1819239
邀请新用户注册赠送积分活动 892655
科研通“疑难数据库(出版商)”最低求助积分说明 815022