亚型
分子诊断学
计算生物学
审问
体细胞
生物
医学
癌症研究
生物信息学
计算机科学
遗传学
政治学
基因
程序设计语言
法学
作者
Joseph Schroers‐Martin,Stefan Alig,Andrea Garofalo,Benoît Tessoulin,Takeshi Sugio,Ash A. Alizadeh
出处
期刊:Annual Review of Pathology-mechanisms of Disease
[Annual Reviews]
日期:2023-01-24
卷期号:18 (1): 149-180
被引量:3
标识
DOI:10.1146/annurev-pathol-050520-044652
摘要
Molecular monitoring of tumor-derived alterations has an established role in the surveillance of leukemias, and emerging nucleic acid sequencing technologies are likely to similarly transform the clinical management of lymphomas. Lymphomas are well suited for molecular surveillance due to relatively high cell-free DNA and circulating tumor DNA concentrations, high somatic mutational burden, and the existence of stereotyped variants enabling focused interrogation of recurrently altered regions. Here, we review the clinical scenarios and key technologies applicable for the molecular monitoring of lymphomas, summarizing current evidence in the literature regarding molecular subtyping and classification, evaluation of treatment response, the surveillance of active cellular therapies, and emerging clinical trial strategies.
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