Association between SII and hepatic steatosis and liver fibrosis: A population-based study

脂肪变性 医学 贝叶斯多元线性回归 内科学 多元统计 纤维化 多元分析 胃肠病学 人口 线性回归 全国健康与营养检查调查 统计 数学 环境卫生
作者
Ruijie Xie,Mengde Xiao,Lihong Li,Nengqian Ma,Mingjiang Liu,Xiongjie Huang,Qianlong Liu,Ya Zhang
出处
期刊:Frontiers in Immunology [Frontiers Media]
卷期号:13 被引量:135
标识
DOI:10.3389/fimmu.2022.925690
摘要

Background The systemic immune-inflammation index (SII) is a novel marker of inflammation, and hepatic steatosis and fibrosis are associated with inflammation. This study aimed to investigate the possible relationship between SII and hepatic steatosis and fibrosis. Methods The datasets from the National Health and Nutrition Examination Survey (NHANES) 2017–2020 were used in a cross-sectional investigation. Multivariate linear regression models were used to examine the linear connection between SII and controlled attenuation parameter (CAP) and liver stiffness measurement (LSM). Fitted smoothing curves and threshold effect analysis were used to describe the nonlinear relationship. Results This population-based study included a total of 6,792 adults aged 18–80 years. In a multivariate linear regression analysis, a significant positive association between SII and CAP was shown [0.006 (0.001, 0.010)]. This positive association in a subgroup analysis was maintained in men [0.011 (0.004, 0.018)] but not in women. Furthermore, the association between SII and CAP was nonlinear; using a two-segment linear regression model, we found an inverted U-shaped relationship between SII and CAP with an inflection point of 687.059 (1,000 cells/µl). The results of the multiple regression analysis showed that the relationship between SII and LSM was not significant (P = 0.263). Conclusions Our findings imply that increased SII levels are linked to hepatic steatosis, but SII is not linked to liver fibrosis. To confirm our findings, more large-scale prospective investigations are needed.
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