Association between SII and hepatic steatosis and liver fibrosis: A population-based study

脂肪变性 医学 贝叶斯多元线性回归 内科学 多元统计 纤维化 多元分析 胃肠病学 人口 线性回归 全国健康与营养检查调查 统计 数学 环境卫生
作者
Ruijie Xie,Mengde Xiao,Lihong Li,Nengqian Ma,Mingjiang Liu,Xiongjie Huang,Qianlong Liu,Ya Zhang
出处
期刊:Frontiers in Immunology [Frontiers Media]
卷期号:13 被引量:135
标识
DOI:10.3389/fimmu.2022.925690
摘要

Background The systemic immune-inflammation index (SII) is a novel marker of inflammation, and hepatic steatosis and fibrosis are associated with inflammation. This study aimed to investigate the possible relationship between SII and hepatic steatosis and fibrosis. Methods The datasets from the National Health and Nutrition Examination Survey (NHANES) 2017–2020 were used in a cross-sectional investigation. Multivariate linear regression models were used to examine the linear connection between SII and controlled attenuation parameter (CAP) and liver stiffness measurement (LSM). Fitted smoothing curves and threshold effect analysis were used to describe the nonlinear relationship. Results This population-based study included a total of 6,792 adults aged 18–80 years. In a multivariate linear regression analysis, a significant positive association between SII and CAP was shown [0.006 (0.001, 0.010)]. This positive association in a subgroup analysis was maintained in men [0.011 (0.004, 0.018)] but not in women. Furthermore, the association between SII and CAP was nonlinear; using a two-segment linear regression model, we found an inverted U-shaped relationship between SII and CAP with an inflection point of 687.059 (1,000 cells/µl). The results of the multiple regression analysis showed that the relationship between SII and LSM was not significant (P = 0.263). Conclusions Our findings imply that increased SII levels are linked to hepatic steatosis, but SII is not linked to liver fibrosis. To confirm our findings, more large-scale prospective investigations are needed.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
AaronDP发布了新的文献求助50
1秒前
terryok完成签到,获得积分10
2秒前
Cll完成签到 ,获得积分10
2秒前
聪明的宛菡完成签到,获得积分10
3秒前
CNYDNZB完成签到 ,获得积分10
3秒前
xxj完成签到 ,获得积分10
3秒前
芊芊完成签到 ,获得积分10
4秒前
yar应助bluesky采纳,获得10
4秒前
海人完成签到 ,获得积分10
5秒前
SY15732023811完成签到 ,获得积分10
7秒前
李建勋完成签到,获得积分10
7秒前
科研通AI2S应助一路芬芳采纳,获得10
7秒前
黄花完成签到 ,获得积分10
8秒前
刘珍荣完成签到,获得积分10
9秒前
9秒前
紫金之巅完成签到 ,获得积分10
9秒前
Gang完成签到,获得积分10
10秒前
11秒前
11秒前
12秒前
CYYDNDB完成签到 ,获得积分10
12秒前
粿粿一定行完成签到 ,获得积分10
13秒前
14秒前
战战完成签到,获得积分10
15秒前
xlk2222完成签到,获得积分10
18秒前
笨笨以莲完成签到,获得积分10
18秒前
YHX完成签到,获得积分10
19秒前
沐沐心完成签到 ,获得积分10
20秒前
20秒前
21秒前
哭泣笑柳发布了新的文献求助10
21秒前
轻松白桃完成签到,获得积分10
21秒前
JasVe完成签到 ,获得积分10
24秒前
wakkkkk完成签到,获得积分10
24秒前
含蓄听南完成签到,获得积分10
24秒前
HH给HH的求助进行了留言
24秒前
芋你呀完成签到,获得积分10
25秒前
西蓝花香菜完成签到 ,获得积分10
25秒前
无花果应助兔子采纳,获得10
25秒前
请勿继续完成签到,获得积分10
27秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038184
求助须知:如何正确求助?哪些是违规求助? 3575908
关于积分的说明 11373872
捐赠科研通 3305715
什么是DOI,文献DOI怎么找? 1819255
邀请新用户注册赠送积分活动 892662
科研通“疑难数据库(出版商)”最低求助积分说明 815022