线粒体生物发生
干细胞
癌症研究
癌症干细胞
生物
胶质母细胞瘤
DNA甲基化
线粒体
生物发生
细胞生物学
遗传学
基因
基因表达
作者
Mengdie Li,Zhixiang Zhang,Liuguijie He,Xiefeng Wang,Jianxing Yin,Xiuxing Wang,Yong-ping You,Qian Xu,Xin Ge,Zhumei Shi
出处
期刊：Neuro-oncology
[Oxford University Press]
日期：2024-05-09
卷期号：26 (9): 1587-1601
标识
DOI：10.1093/neuonc/noae090
摘要
The high fatality rate of glioblastoma (GBM) is attributed to glioblastoma stem cells (GSCs), which exhibit heterogeneity and therapeutic resistance. Metabolic plasticity of mitochondria is the hallmark of GSCs. Targeting mitochondrial biogenesis of GSCs is crucial for improving clinical prognosis in GBM patients.
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