罗亚
细胞生物学
体内
限制
功能(生物学)
体外
鞘氨醇激酶1
势垒函数
化学
生物
信号转导
生物化学
鞘氨醇
受体
1-磷酸鞘氨醇
遗传学
机械工程
工程类
作者
Jinyu Piao,Zhuoxuan Su,Jiqian He,Tianxin Zhu,Faxin Fan,Xin Wang,Zhenzhen Yang,Huixia Zhan,Duosheng Luo
标识
DOI:10.1016/j.cellsig.2024.111252
摘要
S1P is an important factor regulating the function of the vascular endothelial barrier. SphK1 is an important limiting enzyme for the synthesis of S1P. However, the role of the SphK1/S1P-mediated vascular endothelial barrier function in atherosclerosis has not been fully revealed. This study explored the roles and mechanisms of SphK1 on atherosclerosis in vivo and in vitro.
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