阿格里坎
骨关节炎
II型胶原
MAPK/ERK通路
基质金属蛋白酶
医学
软骨寡聚基质蛋白
癌症研究
软骨
激酶
炎症
蛋白激酶A
阿达姆斯
肿瘤坏死因子α
关节炎
血栓反应素
药理学
免疫学
金属蛋白酶
化学
内科学
病理
生物化学
关节软骨
解剖
替代医学
作者
Doo Ri Park,Bo Ram Choi,Changhwan Yeo,Jee Eun Yoon,Eun Young Hong,Seung Ho Baek,Yoon Jae Lee,In‐Hyuk Ha
出处
期刊:PLOS ONE
[Public Library of Science]
日期:2024-05-08
卷期号:19 (5): e0302906-e0302906
标识
DOI:10.1371/journal.pone.0302906
摘要
Osteoarthritis is the most prevalent type of degenerative arthritis. It is characterized by persistent pain, joint dysfunction, and physical disability. Pain relief and inflammation control are prioritised during osteoarthritis treatment Mume Fructus (Omae), a fumigated product of the Prunus mume fruit, is used as a traditional medicine in several Asian countries. However, its therapeutic mechanism of action and effects on osteoarthritis and articular chondrocytes remain unknown. In this study, we analyzed the anti-osteoarthritis and articular regenerative effects of Mume Fructus extract on rat chondrocytes. Mume Fructus treatment reduced the interleukin-1β-induced expression of matrix metalloproteinase 3, matrix metalloproteinase 13, and a disintegrin and metalloproteinase with thrombospondin type 1 motifs 5. Additionally, it enhanced collagen type II alpha 1 chain and aggrecan accumulation in rat chondrocytes. Furthermore, Mume Fructus treatment regulated the inflammatory cytokine levels, mitogen-activated protein kinase phosphorylation, and nuclear factor-kappa B activation. Overall, our results demonstrated that Mume Fructus inhibits osteoarthritis progression by inhibiting the nuclear factor-kappa B and mitogen-activated protein kinase pathways to reduce the levels of inflammatory cytokines and prevent cartilage degeneration. Therefore, Mume Fructus may be a potential therapeutic option for osteoarthritis.
科研通智能强力驱动
Strongly Powered by AbleSci AI