In vivo whole-cortex marker of excitation-inhibition ratio indexes cortical maturation and cognitive ability in youth

神经科学 认知 皮质(解剖学) 心理学 阿普唑仑 大脑皮层 连接体 人类连接体项目 精神科 功能连接 焦虑
作者
Shaoshi Zhang,Bart Larsen,Valerie J. Sydnor,Tianchu Zeng,Lijun An,Xiaoxuan Yan,Ru Kong,Xiaolu Kong,Ruben C. Gur,Raquel E. Gur,Tyler M. Moore,Daniel H. Wolf,Avram J. Holmes,Yapei Xie,Juan Zhou,Marielle V. Fortier,Ai Peng Tan,Peter D. Gluckman,Yap Seng Chong,Michael J. Meaney,Gustavo Deco,Theodore D. Satterthwaite,B.T. Thomas Yeo
出处
期刊:Proceedings of the National Academy of Sciences of the United States of America [National Academy of Sciences]
卷期号:121 (23) 被引量:3
标识
DOI:10.1073/pnas.2318641121
摘要

A balanced excitation-inhibition ratio (E/I ratio) is critical for healthy brain function. Normative development of cortex-wide E/I ratio remains unknown. Here, we noninvasively estimate a putative marker of whole-cortex E/I ratio by fitting a large-scale biophysically plausible circuit model to resting-state functional MRI (fMRI) data. We first confirm that our model generates realistic brain dynamics in the Human Connectome Project. Next, we show that the estimated E/I ratio marker is sensitive to the gamma-aminobutyric acid (GABA) agonist benzodiazepine alprazolam during fMRI. Alprazolam-induced E/I changes are spatially consistent with positron emission tomography measurement of benzodiazepine receptor density. We then investigate the relationship between the E/I ratio marker and neurodevelopment. We find that the E/I ratio marker declines heterogeneously across the cerebral cortex during youth, with the greatest reduction occurring in sensorimotor systems relative to association systems. Importantly, among children with the same chronological age, a lower E/I ratio marker (especially in the association cortex) is linked to better cognitive performance. This result is replicated across North American (8.2 to 23.0 y old) and Asian (7.2 to 7.9 y old) cohorts, suggesting that a more mature E/I ratio indexes improved cognition during normative development. Overall, our findings open the door to studying how disrupted E/I trajectories may lead to cognitive dysfunction in psychopathology that emerges during youth.
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