骨质疏松症
微泡
细胞生物学
PI3K/AKT/mTOR通路
地幔(地质学)
牡蛎
医学
癌症研究
信号转导
内科学
生物
小RNA
生物化学
生态学
古生物学
基因
作者
Yuanyuan Hu,Zuoxu Hou,Zhengqi Liu,Xiao Wang,Jintao Zhong,Jinjin Li,Xiaoming Guo,Changshun Ruan,Hongxun Sang,Beiwei Zhu
出处
期刊:Biomaterials
[Elsevier]
日期:2024-05-31
卷期号:311: 122648-122648
被引量:1
标识
DOI:10.1016/j.biomaterials.2024.122648
摘要
Osteoporosis is a major public health problem with an urgent need for safe and effective therapeutic interventions. The process of shell formation in oysters is similar to that of bone formation in mammals, and oyster extracts have been proven to exert osteoprotective effects. Oyster mantle is the most crucial organ regulating shell formation, in which exosomes play an important role. However, the effects of oyster mantle-derived exosomes (OMEs) on mammalian osteoporosis and the underlying mechanisms remain unknown. The OMEs investigated herein was found to carry abundant osteogenic cargos. They could also survive hostile gastrointestinal conditions and accumulate in the bones following oral administration. Moreover, they promoted osteoblastic differentiation and inhibited osteoclastic differentiation simultaneously. Further mechanistic examination revealed that OMEs likely promoted osteogenic activity by activating PI3K/Akt/β-catenin pathway in osteoblasts and blunted osteoclastic activity by inhibiting NF-κB pathway in osteoclasts. These favorable pro-osteogenic effects of OMEs were also corroborated in a rat femur defect model. Importantly, oral administration of OMEs effectively attenuated bone loss and improved the bone microstructure in ovariectomy-induced osteoporotic mice, and demonstrating excellent biosafety. The mechanistic insights from our data support that OMEs possess promising therapeutic potential against osteoporosis.
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